Results 121 to 130 of about 17,995 (289)

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

ALMA-LEGUS. I. The Influence of Galaxy Morphology on Molecular Cloud Properties

The Astrophysical Journal
We present a comparative study of the molecular gas in two galaxies from the Legacy ExtraGalactic UV Survey (LEGUS) sample: barred spiral NGC 1313 and flocculent spiral NGC 7793.
Molly K. Finn, Kelsey E. Johnson, Remy Indebetouw, Allison H. Costa, Angela Adamo, Alessandra Aloisi, Lauren Bittle, Daniela Calzetti, Daniel A. Dale, Clare L. Dobbs, Jennifer Donovan Meyer, Bruce G. Elmegreen, Debra M. Elmegreen, Michele Fumagalli, J. S. Gallagher, Kathryn Grasha, Eva K. Grebel, Robert C. Kennicutt, Mark R. Krumholz, Janice C. Lee, Matteo Messa, Preethi Nair, Elena Sabbi, Linda J. Smith, David A. Thilker, Bradley C. Whitmore, Aida Wofford   +26 more
doaj   +1 more source

Integrated Opto–Biomechatronics For Single Muscle Fibre Structure‐Function Assessment: The MyoRobot 3.0

Advanced Science, EarlyView.
We present the MyoRobot 3.0, an advanced platform that combines high‐resolution imaging with automated mechanical testing to improve the accuracy of single muscle fibre analysis. The system tracks fibre diameter changes during stretch, preventing major stress miscalculations.
Michael Haug, Moritz Hellmann, Larysa Kovbasyuk, Maria Eleni Vazakidou, Milena Theis, Oliver Friedrich   +5 more
wiley   +1 more source

Nowhere Left to Hide: Uncovering All of the Massive Young Embedded Star Clusters in the Antennae with JWST

The Astrophysical Journal
The Antennae galaxies merger produces the brightest infrared emission of any galaxy within ≈20 Mpc, mostly from intense star formation taking place in supergiant molecular cloud complexes in the overlap region.
Rupali Chandar, Miranda Caputo, Paul Goudfrooij, Sean T. Linden, Angus Mok, Cory Whitcomb, Grant Donnelly, Florent Renaud, John-David T. Smith, Alberto Bolatto, Danny A. Dale, Sara Duval, Lindsey Hands, Ralf Klessen, Caroline Kuczek, Karin Sandstrom, Eva Schinnerer, Fabian Walter   +17 more
doaj   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

TWO POPULATIONS OF YOUNG MASSIVE STAR CLUSTERS IN ARP 220 [PDF]

, 2005
We present new optical observations of young massive star clusters in Arp 220, the nearest ultraluminous infrared galaxy, taken in UBVI with the Hubble Space Telescope ACS HRC camera. We find a total of 206 probable clusters whose spatial distribution is
N. Z. Scoville, Rebecca Longden, William E. Harris, Christine D. Wilson   +3 more
core  

Investigating rotation in young massive clusters by means of hydrodynamical and direct N-body simulations [PDF]

, 2022
One of the main open questions of star formation is the process of star clusters aggregation. In my thesis I investigate the kinematical features of embedded star clusters through hydrodynamical and N-body simulations.
Di Carlo, Ugo Niccolò
core  

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

The expansion of massive young star clusters- observation meets theory [PDF]

, 2013
Context. Most stars form as part of a star cluster. The most massive clusters in the Milky Way exist in two groups- loose and compact clusters- with significantly different sizes at the end of the star formation process.
Susanne Pfalzner, Thomas Kaczmarek
core   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source