Results 131 to 140 of about 190,834 (283)

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Probing Hadronic γ-Ray and High-energy Neutrino Emission from Gaia DR2 Star Clusters

The Astrophysical Journal
Young and massive stellar clusters are a potential source of galactic cosmic rays due to at least two acceleration mechanisms. Collective stellar winds from massive stars form a wind-blown bubble with a termination shock at which particle acceleration to
Alison M. W. Mitchell, Giovanni Morlino, Silvia Celli, Stefano Menchiari, Andreas Specovius   +4 more
doaj   +1 more source

Rejuvenated Amorphous Alloys: Processing Methods, Microstructures and Mechanical Properties

Advanced Science, EarlyView.
Three rejuvenation methods – mechanical and thermal rejuvenation, and other rejuvenation routes such as ultrasonic processing – can be used to modify structures of glassy alloys, especially atomic clusters, and therefore enhances plasticity and activates work‐hardening behaviors.
Can Yang, Yu Chen, Chunguang Tang, Si Lan, Jun Tan, Heng Ye, Hua Chen, Zhifu Yao, Jürgen Eckert, Dongxian Zhang, Jian‐Zhong Jiang   +10 more
wiley   +1 more source

Intermediate-mass Black Hole Progenitors from Stellar Collisions in Dense Star Clusters

The Astrophysical Journal
Very massive stars (VMSs) formed via a sequence of stellar collisions in dense star clusters have been proposed as the progenitors of massive black hole seeds.
Elena González Prieto, Newlin C. Weatherford, Giacomo Fragione, Kyle Kremer, Frederic A. Rasio   +4 more
doaj   +1 more source

Euclid: Early Release Observations – The star cluster systems of the Local Group dwarf galaxies IC 10 and NGC 6822★

Astronomy & Astrophysics
Star clusters are valuable indicators of galaxy evolution, offering insights into the buildup of stellar populations across cosmic time. Understanding the intrinsic star cluster populations of dwarf galaxies is particularly important given these systems’
Howell J. M., Ferguson A. M. N., Larsen S. S., Lançon A., Annibali F., Cuillandre J.-C., Hunt L. K., Martínez-Delgado D., Massari D., Saifollahi T., Voggel K., Altieri B., Andreon S., Auricchio N., Baccigalupi C., Baldi M., Bardelli S., Biviano A., Branchini E., Brescia M., Brinchmann J., Camera S., Cañas-Herrera G., Candini G. P., Capobianco V., Carbone C., Carretero J., Castellano M., Castignani G., Cavuoti S., Cimatti A., Colodro-Conde C., Congedo G., Conselice C. J., Conversi L., Copin Y., Courbin F., Courtois H. M., Cropper M., Da Silva A., Degaudenzi H., De Lucia G., Dubath F., Duncan C. A. J., Dupac X., Dusini S., Escoffier S., Farina M., Farinelli R., Faustini F., Ferriol S., Finelli F., Frailis M., Franceschi E., Fumana M., Galeotta S., George K., Gillis B., Giocoli C., Gracia-Carpio J., Grazian A., Grupp F., Haugan S. V. H., Hoekstra H., Holmes W., Hormuth F., Hornstrup A., Jahnke K., Jhabvala M., Keihänen E., Kermiche S., Kubik B., Kümmel M., Kunz M., Kurki-Suonio H., Le Brun A. M. C., Le Mignant D., Ligori S., Lilje P. B., Lindholm V., Lloro I., Mainetti G., Maino D., Maiorano E., Mansutti O., Marggraf O., Martinelli M., Martinet N., Marulli F., Massey R. J., Medinaceli E., Mei S., Melchior M., Mellier Y., Meneghetti M., Merlin E., Meylan G., Mora A., Moresco M., Moscardini L., Nakajima R., Neissner C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Percival W. J., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Raison F., Renzi A., Rhodes J., Riccio G., Romelli E., Roncarelli M., Saglia R., Sakr Z., Sapone D., Sartoris B., Schirmer M., Schneider P., Schrabback T., Secroun A., Seidel G., Serrano S., Simon P., Sirignano C., Sirri G., Skottfelt J., Stanco L., Steinwagner J., Tallada-Crespí P., Taylor A. N., Teplitz H. I., Tereno I., Toft S., Toledo-Moreo R., Torradeflot F., Tutusaus I., Valenziano L., Valiviita J., Vassallo T., Wang Y., Weller J., Zamorani G., Zinchenko I. A., Martín-Fleitas J., Scottez V.   +151 more
doaj   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Hubble Space Telescope proper motions of Large Magellanic Cloud star clusters

Astronomy & Astrophysics
In this paper, we explore the kinematic properties of a sample of 19 young (
Niederhofer F., Cullinane L., Massari D., Bastian N., Bellini A., Aguado-Agelet F., Cassisi S., Erkal D., Libralato M., Kacharov N., Cabrera-Ziri I., Ceccarelli E., Cioni M.-R. L., Dresbach F., Häberle M., Martocchia S., Saracino S.   +16 more
doaj   +1 more source

Enhanced Resistive Switching Uniformity in Tantalum Oxide Memristor Devices via Copper Implantation

Advanced Electronic Materials, EarlyView.
Metal oxide memristor devices typically suffer from uncontrolled forming processes and limited resistive switching uniformity due to the stochastic formation of an oxygen vacancy filament. Improved resistive switching uniformity in Ta2O5 memristor is developed by Cu implantation in the switching oxide.
Shaochuan Chen, Ilia Valov
wiley   +1 more source

Alcohol‐Adduct Mediated Precursor Stabilization Strategies for Conformal SnO2 Layers in Highly Efficient and Stable Perovskite Solar Modules

Advanced Energy Materials, EarlyView.
An alcohol‐adduct‐mediated strategy is employed to stabilize tin isopropoxide for the formation of a homogeneous double electron transport layer (ETL) incorporating SnO2 nanoparticles (NPs). This double‐ETL exhibits improved optical and charge‐transport properties due to reduced defect density and better energy level alignment, resulting in high ...
You‐Hyun Seo, Eun Young Park, Chan Su Moon, Dong Gyu Lee, Junho Park, Fabian Rotermund, Gill Sang Han, Tae Kyung Lee, Nam Joong Jeon, Bong Joo Kang, Young Yun Kim   +10 more
wiley   +1 more source