Results 131 to 140 of about 2,750,733 (346)

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han   +16 more
wiley   +1 more source

HEY Statistics: Employment Barriers for Current & Former Foster Youth [PDF]

open access: yes, 2010
HEY Statistics paint a picture of the barriers foster youth face while searching for and keeping employment. Foster youth often have more barriers to finding and keeping jobs than youth who are connected to a family, and the emotional and economic ...

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Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

open access: yesAdvanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui   +6 more
wiley   +1 more source

From Page to Stage to Screen and Beyond [PDF]

open access: yes, 2012
A group of Chicago youth media organizations have embarked on an evaluation process with adult program alumni to assess the degree to which hands-on media production and dissemination contributes to developing productive, independent, and engaged ...
Amy Terpstra, Suniya Farooqui
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Releasing 8.0 wt.% H2 from the LiBH4−2LiNH2 Composite within 5 Min under Light Illumination

open access: yesAdvanced Science, EarlyView.
The N−H bond in the [NH2]− ion group is significantly weakened by the non‐thermal effect of UV light, leading to a 60‐fold increase in dehydrogenation rate at the same temperature. As a result, over 8.0 wt.% H2 is released within 5 min. Abstract The absence of safe and efficient hydrogen storage technologies is the major bottleneck for widespread ...
Haoyang Yu   +7 more
wiley   +1 more source

The Beacon Community Centers Middle School Initiative: Final Report on Implementation and Youth Experience in the Initiative [PDF]

open access: yes, 2011
The report evaluates New York City's Beacon Middle School Initiative, which was launched to increase services to middle-grades youth through programs in academics, life skills, career awareness, civic engagement, physical health, and arts and culture ...
Christina A. Russell   +3 more
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MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen   +12 more
wiley   +1 more source

A Comparison by Race of Juvenile Referrals in Alaska [PDF]

open access: yes, 1998
This paper is a based on the report A Comparison by Race of Juvenile Referrals in Alaska: Phase II Report by N.E. Schafer (Anchorage, AK: Justice Center, University of Alaska Anchorage, May 1998).A data set comprised of all juveniles referred to Alaska ...
Schafer, N. E.
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