Results 131 to 140 of about 2,725,128 (312)

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Youth-to-Youth Engagement

International Journal of Recent Technology and Engineering, 2019
Youth-to-youth engagement develops as well as enhances sense of belonging, autonomy and power control, competence, motivation and decision-making skills. Millennial youth are self-learned generation; thus, peer influence is vital. Based on these premises, GENIUS Remaja programmes are created ‘with youths’ rather than ‘for youth’.
openaire   +1 more source

Supporting Youth Employment: A Guide for Community Groups [PDF]

, 2002
Although public money is available for education, job training and youth programs throughout the nation, many young people in low-income communities do not acquire the skills and credentials necessary to get high paying jobs. This Guide is a resource for
Carol Clymer, Joseph Ponce, Keisha Edwards, Laura Wyckoff   +3 more
core  

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

A systematic survey of type I secretion systems and their substrate proteins in Salmonella

Virulence
Type I secretion systems (T1SSs) and the substrates have not been investigated extensively in Salmonella, despite their potential significance. In this research, we screened the comprehensive list of Salmonella T1SSs, observed their evolution and ...
Mingyang Yu, Yating Chen, Xin Cao, Zefan Chen, Shichao Su, Jiamin Wu, Leting Sun, Qiqi Lu, Chenxia Zhang, Zhixuan Deng, Jialin Li, Jingchao Zhong, Yejun Wang   +12 more
doaj   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Immigrant Youth and Digital Disparty in California [PDF]

, 2006
This study addresses three key research questions regarding immigrant youth and the digital divide:What are the patterns of home technology use among native-born and immigrant families and youth?What are the causes and consequences of the digital divide ...
Rob Fairlie
core  

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Axis Specific Player Load to Quantify Lower Limb Biomechanical Loading in Adolescent Badminton Players

International Journal of Racket Sports Science
While the use of accelerometer derived Player Load has become increasingly prominent, the limitation of this approach is that training load is reduced to a single number with no differentiation between the mechanisms of loading, resulting in a loss of ...
Matthew James Wylde, Baranee Kumar, Low Chee Yong, Andrew James Callaway   +3 more
doaj  

Emancipated Foster Youth Returning to Birth Parents [PDF]

, 2010
Although foster youth should only emancipate from care if reunification or adoption is not possible by the time the youth must age out, some youth still return to the same families from whom they were ...

core