Results 201 to 210 of about 1,114,646 (307)

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Measurement-Based Care (MBC) in the child and adolescent obsessive-compulsive disorder (OCD) programme in Calgary: study protocol. [PDF]

BMJ Open
Bajgain B, McCabe E, Arnold P, Santana MJ, Zwicker J.   +4 more
europepmc   +1 more source

Youth Voice / Youth Action / Youth Justice

Experiments in Democracy
openaire   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Linking Emotion Dysregulation to Autistic Traits Across Neurodiverse Samples. [PDF]

Autism
McDonald RG, Cargill MI, Lynch E, Khawar S, Freden C, Kang E.   +5 more
europepmc   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

A Randomized Clinical Trial of the Acceptability and Preliminary Effectiveness of an Online CBT Platform in Diverse Youth. [PDF]

Brain Sci
Weiss MD, Aldis R, Bien-Aime DDR, Witkowski T, Williams P, Holmes KE, Cortés DE, Wang PS, Cook BL, Richards EC.   +9 more
europepmc   +1 more source

Balancing Carrier Cooling in InN/GaN Quantum Wells via Point Defect Engineering

Advanced Electronic Materials, EarlyView.
Nitrogen vacancies in the InN/GaN interface regulate carrier relaxation in polar quantum wells by reconstructing the conduction‐band decay pathway and enhancing nonadiabatic coupling. No deep midgap state is introduced in the neutral single‐vacancy model, enabling faster hot‐electron cooling, improved electron‐hole balance, reduced electron overflow ...
Yuxin Yang, Zhiming Shi, Zi‐Hui Zhang, Su‐Huai Wei, Xiaojuan Sun, Dabing Li   +5 more
wiley   +1 more source

Youth participation coach learning: A scoping review. [PDF]

PLoS One
Tan LQW, Barkell J, O'Connor D.
europepmc   +1 more source