Results 41 to 50 of about 85,182 (263)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

The use of synchronized swimming exercises in the process of students physical education

BIO Web of Conferences, 2020
The article presents an analysis of the motives, needs, interests, beliefs and students valuable orientations to the physical culture and sport. The study showed that it is necessary to modernize the process of physical education and improve some ...
Raspopova Evgeniya, Postolnik Julia, Maltsev Dmitry   +2 more
doaj   +1 more source

A review of the research in teaching and learning the negative numbers: an “action research” concerning the application of the geometrical model of the number line

Didattica della Matematica, 2022
The notion of negative numbers is one of the most fundamental in mathematics. For many years, they have caused confusion and they have been an object of controversy among great researchers, until the development of symbolic algebra led to their ...
Athanasios Gagatsis, Maria Alexandrou
doaj   +1 more source

Mining mobile youth cultures [PDF]

2014 IEEE International Conference on Big Data (Big Data), 2014
In this short paper we discuss our work on co-research devices with a young coder community, which help investigate big social data collected by mobile phones. The development was accompanied by focus groups and interviews on privacy attitudes and aims to explore how youth cultures are tracked in mobile phone data.
Tobias Blanke, Giles Greenway, Jennifer Pybus, Mark Coté   +3 more
openaire   +2 more sources

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Knowledge, Attitudes, and Behavior Regarding Health and Environment in an Israeli Community: Implications for Sustainable Urban Environments and Public Health

World
Over the past two decades, public health researchers have increasingly emphasized the need to adopt a new, comprehensive approach to the environment that addresses social and spatial aspects of urban life affecting public health in urban areas.
Keren Dopelt, Liza Aharon, Miri Rimon
doaj   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, EarlyView.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

Technology of physical and coordination-technical improvement of firefighters and rescuers in training activities

BIO Web of Conferences, 2020
The study defines pedagogical conditions that contribute to the growth of sports skills of men 19-23 years old, competing in fire and rescue sports. The conditions provide knowledge of the competitive activity laws implementation.
Shalaginov Vasilij, Germanov Gennady, Grigorieva Elena, Korolkov Alexey, Kochetkova Ekaterina   +4 more
doaj   +1 more source

Emergence of (Hybrid) Youth Cultures [PDF]

Communication Theory, 2018
El artículo se aproxima a las teorías sobre comunicación en / desde América Latina, a partir de la obra de la antropóloga mexicana Rossana Reguillo, en particular de su libro Culturas juveniles, publicado originalmente en 2000 y reeditado en 2012, que ha tenido un gran impacto en los estudios culturales, sobre comunicación y juventud.
Feixa, Carles, Figueras-Maz, Mònica
openaire   +2 more sources