Results 141 to 150 of about 16,224,136 (409)

Aging and the Spectral Properties of Brain Hemodynamics

Advanced Science, EarlyView.
As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park, Abraham Z. Snyder, Manu S. Goyal, Timothy O. Laumann, John J. Lee, Babatunde Adeyemo, Nicholas Metcalf, Andrei G. Vlassenko, Joshua S. Shimony, Eric C. Leuthardt   +9 more
wiley   +1 more source

Matching Traffic Safety Strategies to Youth Characteristics: A Literature Review of Cognitive Development [PDF]

, 1998
David W. Eby, Lisa J. Molnar
openalex   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Exploring the Multidimensional Characteristics of Selected and Non-Selected White British and British South Asian Youth Cricketers: An Exploratory Machine Learning Approach

Youth
Selection into a County Age Group (CAG; under 10–18) programme is the first step for young aspiring cricketers on their journey to achieving professional status.
Tom Brown, Robert Cook, Lewis A. Gough, Irfan Khawaja, Alexander B. T. McAuley, Adam L. Kelly   +5 more
doaj   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Competitive Match Running Speed Demands and Impact of Changing the Head Coach in Non-League Professional Football

Sensors
Match running speed demands vary across competitive levels of football, influenced by player position, tactical considerations, and Head Coach changes. In England, the level directly below professional football, Non-League Football (NLF), comprises full ...
Daniel T. Jackson, Richard C. Blagrove, Peter K. Thain, Anthony Weldon, Cain C. T. Clark, Adam L. Kelly   +5 more
doaj   +1 more source

Parental Engagement [PDF]

, 2008
The relationships between youth and parents is a central element in the successful development of healthy teens. In this guide, Healthy Teen Network recognizes the importance of adults in a young person's life and of the need to provide support and ...

core  

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Characteristics of nitrogen and phosphorus contents in soil and water in an agricultural catchment of the three Gorges reservoir area

Frontiers in Environmental Science
To explore the impact of different land use modes on the contents of nitrogen and phosphorus in soil and water in the agricultural basin of the Three Gorges Reservoir, the differences in the nitrogen and phosphorus contents in soil and shallow ...
Chenglong Chen, Hua Deng, Guixin Xin, Youwen Zhou   +3 more
doaj   +1 more source

CHRIMCY: A proposed institute for research on reproduction, development, and mother, child and youth health [PDF]

, 2000
H. Guyda, Robert W. Armstrong, Ken Milne, Alex MacKenzie, Victor K. M. Han, Robert Bortolussi, Elaine Orrbine   +6 more
openalex   +1 more source