Results 121 to 130 of about 15,301,258 (261)

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Prevalence and comorbidity of mental health concerns, alcohol and drug use among young women in the urban slums of Kampala, Uganda: findings from the TOPOWA study

BMC Public Health
Background Young women in Kampala’s urban slums face a growing public health crisis as mental health issues and substance use escalate, fueled by poverty, violence, and limited access to care. These overlapping challenges significantly heighten the risks
Monica H. Swahn, Jane Palmier, Charles Natuhamya, Kate Mobley, Kevin B. Gittner, Matthew Lyons, Godfrey S. Bbosa, Gideon Matovu, Frank Mubiru, Anna Kavuma   +9 more
doaj   +1 more source

Youth Development as a Product of Social Development: A Sociological Study of Youth and Development in Iran

Journal of Social Sciences, 2009
The paper explores the roots, causes and effects of youth development. Almost half of the world's population is under the age of twenty-five, and nearly 90% of these young people live in the Third World countries. The example of Iran has been chosen to reflect a picture of Youths in a small part of the developing world.
openaire   +1 more source

Policy position paper : students at risk of disengaging

, 2016
Bill T. Hansell, M.S., Youth Development Policy Analyst, Youth Development Council.Title from PDF caption (viewed on July 10, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It

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Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

The role of youth engagement in positive youth development and social justice youth development for high-risk, marginalised youth

International Journal of Adolescence and Youth, 2015
This article describes reflective experiences documented by our youth leaders and community agency partners (n = 7 & 12, respectively) who have involved in our multi-year community-based research project. Overall, meaningful youth engagement facilitated by youth leadership was highlighted as a key mechanism for positive youth development (PYD) and ...
openaire   +2 more sources

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Supporting social-emotional and behavioral skills in preschool children through gymnastics

BMC Pediatrics
Background This study aimed to evaluate the effects of a structured basic gymnastics education program on the social-emotional and behavioral skills of preschool children.
Emre Yamaner, Özlem Bal, Merve Girgin, Kerim Aktaş, Nisa Gökden Kaya, Fatime Sabahat Işıktekiner   +5 more
doaj   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Youth employment in Oregon [PDF]

, 2016
Title from PDF caption (viewed on June 30, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

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