Results 121 to 130 of about 270,371 (267)

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Positive Integration and Positive Youth Development With Adolescents and Young Adults Who Are Refugees or Migrants. [PDF]

J Adolesc Health
Oscós-Sánchez MÁ, Barral RL, Castro-Ramírez F, McPherson LE, Morris DE, Raymond-Flesch M, Svetaz MV.   +6 more
europepmc   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Editorial: Exploring life skills and positive youth development through sports. [PDF]

Front Sports Act Living
Muñoz-Llerena A, Hernández-Hernández E, Murta L, Lagunes-Carrasco JO.   +3 more
europepmc   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Parental Marital Satisfaction and Suicidal Behavior in Preadolescents and Adolescents: The Mediating Role of Positive Youth Development Attributes. [PDF]

Int J Environ Res Public Health
Shek DTL, Tang Y, Li X, Zhao L.
europepmc   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Positive youth development from early adolescence to young adulthood in nine countries: Intercepts, trajectories, and associations with parental warmth and behavioral control. [PDF]

J Res Adolesc
Bornstein MH, Gorla L, Rothenberg WA, Lansford JE, Bacchini D, Chang L, Deater-Deckard K, Fonseca G, Di Giunta L, Dodge KA, Gurdal S, Junla D, Oburu P, Pastorelli C, Skinner AT, Sorbring E, Steinberg L, Uribe Tirado LM, Yotanyamaneewong S, Alampay LP, Al-Hassan SM, Lerner RM.   +21 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

A Systematic Review of Longitudinal Studies on Youth Internet Behavior Using the Positive Youth Development Frameworks. [PDF]

J Adolesc
Sirisety M, Datti RS, Mishra N, Tewari A, Akkaraju S, Sampathirao R.   +5 more
europepmc   +1 more source