Results 121 to 130 of about 1,801,862 (314)

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Environmental perceptions and social support as predictors of continued participation in nighttime physical activity

BMC Public Health
Objective Guided by the Theory of Planned Behavior (TPB), this study investigates how perceived environment and social support are associated with the intention to sustain nighttime physical activity, with attitude tested as a mediating variable. Methods
Minghui Zhao, Jingtao Wu, Yanhong Shao, Jingying Chen, Li Ling   +4 more
doaj   +1 more source

Roadblocks to independence: exploring the roles of self-determination and anxiety on daily living skills in autistic transition-aged youth

Frontiers in Psychiatry
IntroductionAutistic individuals tend to have lower daily living skills than age-matched peers, and lower skills than what would be predicted by cognitive ability. What is less known are the mechanisms contributing to this profile.
Paige Hemming, Alexandra Kalinyak, Chuong Bui, Susan White   +3 more
doaj   +1 more source

Assessing the Enhanced Ranch Program of the Santa Clara County Probation Department [PDF]

, 2010
In 2006, the Santa Clara County Probation Department (SCCPD) changed its approach to serving youth in two of its juvenile justice programs--the William F. James Boys' Ranch and the Muriel Wright Center.
Antoinette Davis, Dana Linda, Isami Arifuku   +2 more
core  

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Pathways to Progress: Setting the Stage for Impact [PDF]

, 2015
Through this three-year Pathways to Progress portfolio review, Equal Measure will Provide a comprehensive narrative about the reach the Citi Foundation investment has had on youth, individual programs, and the grantee organizations.  We also will examine

core  

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Achieving Results Through Community School Partnerships [PDF]

, 2012
Outlines the importance of and strategies for building and maintaining successful partnerships for community schools that integrate academics, youth development, family support, health and social services, and community development.
Atelia Melaville, Martin J. Blank, Reuben Jacobson   +2 more
core  

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

Prevalence and comorbidity of mental health concerns, alcohol and drug use among young women in the urban slums of Kampala, Uganda: findings from the TOPOWA study

BMC Public Health
Background Young women in Kampala’s urban slums face a growing public health crisis as mental health issues and substance use escalate, fueled by poverty, violence, and limited access to care. These overlapping challenges significantly heighten the risks
Monica H. Swahn, Jane Palmier, Charles Natuhamya, Kate Mobley, Kevin B. Gittner, Matthew Lyons, Godfrey S. Bbosa, Gideon Matovu, Frank Mubiru, Anna Kavuma   +9 more
doaj   +1 more source