Results 111 to 120 of about 373,181 (317)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

NYS youth development indicators symposium

, 2005
This report documents the 2004 New York State Youth Development Indicators Symposium. Co-sponsored by the NYS Office of Children and Family Services and the ACT for Youth Centers of Excellence, the Symposium provided a forum for in-depth discussion on ...
ACT for Youth Center of Excellence
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Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Prevalence and comorbidity of mental health concerns, alcohol and drug use among young women in the urban slums of Kampala, Uganda: findings from the TOPOWA study

BMC Public Health
Background Young women in Kampala’s urban slums face a growing public health crisis as mental health issues and substance use escalate, fueled by poverty, violence, and limited access to care. These overlapping challenges significantly heighten the risks
Monica H. Swahn, Jane Palmier, Charles Natuhamya, Kate Mobley, Kevin B. Gittner, Matthew Lyons, Godfrey S. Bbosa, Gideon Matovu, Frank Mubiru, Anna Kavuma   +9 more
doaj   +1 more source

Youth Development as a Product of Social Development: A Sociological Study of Youth and Development in Iran

Journal of Social Sciences, 2009
The paper explores the roots, causes and effects of youth development. Almost half of the world's population is under the age of twenty-five, and nearly 90% of these young people live in the Third World countries. The example of Iran has been chosen to reflect a picture of Youths in a small part of the developing world.
openaire   +1 more source

Youth Leadership Development and Sport

, 2010
The youth of today need to develop leadership skills in order to enjoy greater success in their lives. Therefore, it is important there be programs that can help them cultivate their skills.
Howell, Jodi C
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Youth volunteering in Australia: An evidence review [PDF]

, 2015
Provides evidence and potential policy options to inform federal, state and territory government efforts to increase youth volunteering. Summary The National Youth Affairs Research Scheme commissioned the Australian Research Alliance for Children and ...
Rosalyn Black, Lucas Walsh
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Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

The Iowa 4-H Youth Development Experience

, 2003
4-H youth programs provide opportunities for youth to develop skills they can use now and throughout their life. Iowa 4-H builds upon a century of experience as it fosters positive youth development that is based on the needs and strengths of youth ...
Bogue, Sue, Morris, Chuck
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