Results 111 to 120 of about 3,444,624 (352)

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang   +11 more
wiley   +1 more source

De la Loi sur la protection de la jeunesse au Système d’intervention d’autorité atikamekw (SIAA)-La prise en charge d’une nation pour assurer le bien-être de ses enfants

open access: yesEnfances, Familles, Générations, 2016
This article is concerned with the application of the Youth Protection Act in Aboriginal settings in Quebec and more specifically with the initiatives taken in this regard by the Atikamekw nation.
Anne Fournier
doaj  

The Current Status of Migrant Children under International Public Law

open access: yesRevista Tribuna Internacional, 2012
This paper aims to a double objective: first, an attempt to briefly identify, characterize and analyze the phenomenon of child and youth migration, and secondly, to provide an overview of the legal dimension of this social phenomenon.
Rita Lages
doaj   +1 more source

Child Protection Services and Youth Experiencing Homelessness: Findings of the 2019 National Youth Homelessness Survey in Canada

open access: yesChildren and youth services review, 2023
A. Bonakdar   +5 more
semanticscholar   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang   +9 more
wiley   +1 more source

Child and Youth Victimization Known to Police, School, and Medical Authorities. [PDF]

open access: yes, 2012
Presents the survey results from the National Survey of Children\u27s Exposure to Violence (NatSCEV) regarding authorities\u27 knowledge of victimization incidents involving children and youth, particularly police, school, and medical authorities ...
Finkelhor, David   +3 more
core   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

open access: yesAdvanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen   +11 more
wiley   +1 more source

Repenser la formation initiale des intervenant·es en protection de la jeunesse : un regard d’étudiant·es et de nouveaux·elles gradué·es

open access: yesSociétés et Jeunesses en Difficulté
The preliminary report of the Special Commission on the Rights of the Child and Youth Protection (2020) highlights that “youth protection practices are insufficiently focused on the participation, mobilization, and collaboration of young people and ...
Olivier Laau-Laurin   +4 more
doaj  

Children's Databases - Safety and Privacy [PDF]

open access: yes, 2006
This report describes in detail the policy background, the systems that are being built, the problems with them, and the legal situation in the UK. An appendix looks at Europe, and examines in particular detail how France and Germany have dealt with ...
Anderson, R   +5 more
core  

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