Results 81 to 90 of about 760,246 (312)

The World Bank and children : a review of activities [PDF]

This paper reviews Bank interventions that supported the welfare of children in the last decade. Though the Bank has always addressed children's development, and protection through its focus of broader economic development, and social protection, it has ...
Kaur, Iqbal, Tzannatos, Zafiris
core  

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Protecting youth mental health, protecting our future [PDF]

World Psychiatry, 2017
Christensen, H., Reynolds, C., Cuijpers, Pim   +2 more
openaire   +2 more sources

Assessing the Need and Receptivity for an Integrated Healthy Sexual and Dating Relationships Intervention for Community College Students [PDF]

, 2017
Background: In emerging adulthood, youth often become involved in more serious romantic relationships. However, many lack the skills to avoid an unplanned pregnancy or sexually transmitted infection (STI), and to ensure a healthy dating relationship ...
Addy, Robert C., Hernandez, Belinda, Johnson Baker, Kimberly, Markham, Christine M., Paat, Yok-Fong, Peskin, Melissa, Santa Maria, Diane M, Schick, Vanessa, Shegog, Ross, Temple, Jeff R, Tortolero, Susan R., Wilkerson, J. Michael   +11 more
core   +2 more sources

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Cultural adaptation and validation of Safety Attitude Questionnaire (SAQ) for child protection services

Child Protection and Practice
Background: Various survey reports published since the 1980s point to the historical persistence of difficult practice conditions for practitioners working in Quebec's youth protection system.
Marie-Joëlle Robichaud, Isabelle-Ann Leclair Mallette, Célyne Lalande, Elisabeth Plante, Rosita Vargas Diaz, Mélanie Bourque   +5 more
doaj   +1 more source

Protection of IDP women, children and youth [PDF]

Forced Migration Review, 2006
The regions of the world characterised by conflict anddisplacement have relatively high fertility rates andyoung populations. Women and children thus constitutearound 80% of IDP populations. Their specific protectioncannot be met without provision of key
Dale Buscher, Carolyn Makinson
doaj  

Outcome Measurement in Nonprofit Organizations: Current Practices and Recommendations [PDF]

, 2001
This report provides a view of the state of outcome measurement as implemented in a number of private nonprofit service organizations engaged in outcome measurement.
Elaine Morley, Elisa Vinson, Harry P. Hatry   +2 more
core  

Dealing with risk in child and family social work: from an anxious to a reflexive professional? [PDF]

, 2014
The rhetoric of risk has become a prominent issue in the field of child and family social work. As a consequence, an emerging politics of fear has re-oriented this field towards managing, controlling, and securing social work practice against risk ...
De Wilde, Lieselot, Roets, Griet, Roose, Rudi, Vyvey, Eline   +3 more
core   +3 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source