Results 61 to 70 of about 760,246 (312)

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

open access: yesAdvanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao   +28 more
wiley   +1 more source

Why and How the Liberalisation of the Cannabis Market in Germany Should Occur

open access: yesWirtschaftsdienst, 2022
This article summarises the arguments in favour of legalising cannabis and makes proposals for the design of the regulatory framework. The main argument for a regulated cannabis market is not the expected tax revenues or the legal jobs that would be ...
Justus Haucap, Leon Knoke
doaj   +1 more source

An Increasing Misalignment Between Crop Distribution and Environmental Resources Under Climate Change in China

open access: yesAdvanced Science, EarlyView.
Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su   +13 more
wiley   +1 more source

Le réseau familial de jeunes adultes hébergés en famille d’accueil jusqu’à leur majorité

open access: yesEnfances, Familles, Générations, 2015
This study documents the family networks of 12 young adults who, over the course of their childhoods, have been placed in foster homes until they reach the age of majority.
Claudine Parent   +6 more
doaj  

Age at entry into the Dutch child protection system of children of parents with intellectual disability: A case-control study

open access: yesChild Protection and Practice
Background: It is well established that children of parents with intellectual disability (ID) are disproportionately involved in child protection. It is important to identify the characteristics of their child protection trajectories. Objective: Children
Lianne Bakkum, Carlo Schuengel
doaj   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

open access: yesAdvanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao   +7 more
wiley   +1 more source

Contacts parent-enfant en contexte de placement : liens entre la sensibilité du parent d’accueil et les réactions des enfants à la suite des contacts

open access: yesEnfances, Familles, Générations, 2019
Research Framework: In Quebec, the Youth Protection Act encourages contact between children and their biological parents following placement in foster care.
Lisa Auger   +2 more
doaj  

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

open access: yesAdvanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang   +14 more
wiley   +1 more source

Do youths graduating in a recession incur permanent losses? [PDF]

open access: yes, 2016
In flexible labor markets, low-educated entrants are harmed by economic downturns, but the penalties are short-lived. High-educated youth are less adversely affected, but the penalties persist longer. It takes about ten years for young cohorts that enter
Cockx, Bart
core   +2 more sources

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

open access: yesAdvanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi   +12 more
wiley   +1 more source

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