Results 51 to 60 of about 2,866,257 (254)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Age at entry into the Dutch child protection system of children of parents with intellectual disability: A case-control study

Child Protection and Practice
Background: It is well established that children of parents with intellectual disability (ID) are disproportionately involved in child protection. It is important to identify the characteristics of their child protection trajectories. Objective: Children
Lianne Bakkum, Carlo Schuengel
doaj   +1 more source

Recent Trends in Youth Labour Markets and Youth Employment Policy in Europe and Central Asia [PDF]

This paper discusses the nature and characteristics of the youth labour market in Europe and Central Asia. The central concern is with the policy response to the substantial youth unemploymen problem emerging with the transition to the market in Central &
Niall O’Higgins
core  

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Les enjeux de la recherche concernant l’enfance et la famille autochtones

Enfances, Familles, Générations, 2016
This article presents a review of the colonial policies that had devastating consequences on Aboriginal children and families, among which residential schools and the enforcement of youth protection regulations.
Sébastien Grammond, Christiane Guay
doaj  

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Les contacts parent-enfant suite au placement en famille substitut : liens avec la stabilité du placement

Enfances, Familles, Générations, 2017
Research Framework : Preschool children are less likely to be reunified to their biological parents after being in foster care and generally have more stable foster placement. However, little is known about the factors associated with stable placement in
Karine Poitras, George M. Tarabulsy
doaj  

Metal Active‐Site Exposure via Ligand Engineering Boosts CO2‐to‐Ethylene Conversion on Cu18 Nanoclusters

Advanced Science, EarlyView.
Through quantitative ligand stripping of [Cu18H17(PR3)10]+ nanoclusters via intramolecular interaction modulation, selectivity for CO2 electroreduction to C2H4 is significantly enhanced. The weakly coordinating ligand triggers dual‐ligand stripping (FEC2H4 = 70.59%), whereas the strongly coordinating ligand results in single‐ligand retention (FEC2H4 ...
Ziqi Chen, Yang Zuo, Yu Zhu, Shuo Zhang, Along Ma, Shiyin Yang, Zhengmao Yin, Xiaoshuang Ma, Shuxin Wang   +8 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Are American Youth Alienated From Organized Religion? [PDF]

, 2004
The purpose of the project is to research the shape and influence of religion and spirituality in the lives of U.S. adolescents; to identify effective practices in the religious, moral, and social formation of the lives of youth; to describe the extent ...
Smith, Christian, National Study of Youth & Religion (U.S.), Denton, Melinda Lundquist, Faris, Robert   +3 more
core   +1 more source