Results 31 to 40 of about 2,866,257 (254)

Quantifying intersecting structural racism in the youth criminal justice system: a whole-population linked administrative data study from Manitoba.

International Journal of Population Data Science, 2022
Objectives Over three decades ago, the Aboriginal Justice Inquiry identified structural racism in Canada’s justice system. Although rates of youth criminal charges and incarcerations have declined substantially since then, it is unclear whether First ...
Marni Brownell, Stephanie Sinclair, Nathan Nickel, Lorna Turnbull, Rick Linden, Rosemary Ricciardelli, Wendy Au, Jennifer Enns, Mariette Chartier, Marcelo Urquia, Alyson Mahar, Elizabeth Wall-Wieler, Dan Chateau, Matthew Sanscartier, Hygiea Casiano, Farzana Quddus, Drew Lambert, Ivy Ferland   +17 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Personal Data Protection Awareness through the Use of YouTube among the Youths in UUM

Journal of ICT in Education, 2021
This paper is to discuss the awareness among the youth in UUM related to personal data protection. The cases of personal data protection increased day by day among the youths. Several awareness programs were done.
Mohamad Fadli Zolkipli, Diviya Shini Rajamanickam   +1 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Youth Participation in Water Governance: Learning from a Youth-Led Programme Design

, 2019
In June 2014, Oxfam convened a participatory youth-led project design workshop as part of its Mekong Regional Water Governance Program (MRWGP) in Cambodia.
Oxfam Youth as Active Citizens Community of Practice
core   +1 more source

RISKS OF DEVIANCE AND SOCIAL SECURITY OF YOUTH

Дискурс, 2016
Since deviance of youth is a result of certain life circumstances and social disadvantage, the author proposes to consider the risks of youth deviance through the prism of social security / protection of this social group.
T. V. Shipunova
doaj   +1 more source

Examining the intersection of child protection and public housing: development, health and justice outcomes using linked administrative data

BMJ Open, 2022
Objective We described development, health and justice system outcomes for children in contact with child protection and public housing.Design Descriptive analysis of outcomes for children known to child protection who also had contact with public ...
John W Lynch, Emma Baker, Alicia Montgomerie, Catia Malvaso, Rhiannon Megan Pilkington   +4 more
doaj   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Le réseau familial de jeunes adultes hébergés en famille d’accueil jusqu’à leur majorité

Enfances, Familles, Générations, 2015
This study documents the family networks of 12 young adults who, over the course of their childhoods, have been placed in foster homes until they reach the age of majority.
Claudine Parent, Marie-Hélène Labonté, Marie-Christine Fortin, Marie-Christine Saint-Jacques, Françoise-Romaine Ouellette, Sylvie Drapeau, Caroline Paré-Lévesque   +6 more
doaj  

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source