Results 101 to 110 of about 457,497 (309)

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Understanding the process of psychological development in youth athletes attending an intensive wrestling camp [PDF]

, 2016
This study used a grounded theory methodology to understand if and how psychological development in youth athletes was facilitated by an ‘intensive’ summer wrestling camp experience.
American Camping Association, Benson P., Bereiter C., Birks M., Connaughton D., Driska A., Eccles J.S., Flett M.R., Gallimore R., Gould D., Gould D., Gould D., Guba E.G., Hellison D., MacDonald D.J., MacNamara Á., MacNamara Á., Mayan M.J., Meichenbaum D., Patton M.Q., Perkins D.N., Schön D., Strauss A.   +22 more
core   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Examining the Relationships among the Coaching Climate, Life Skills Development and Well-Being in Sport [PDF]

, 2018
Using Benson and Saito's framework for positive youth development, we investigated the relationships between the coaching climate, young people's perceived life skills development within sport, and their psychological well-being.
Hayes AF, Hellison D, Jones ML, Justine Allen, King PE, Lorcan D Cronin, Marsh HW, McLaughlin MW, Nunnally JC, Tabachnick BG   +9 more
core   +2 more sources

Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems

Advanced Science, EarlyView.
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li, Mingyu Xie, Nan Jia, Li‐Dong Mo, Qiang Yu, Fanjiang Zeng, Xiangyi Li   +6 more
wiley   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Development of an observational measure assessing program quality processes in youth sport

Cogent Social Sciences, 2018
Research has demonstrated that quality sport programs have the potential to foster the physical and psychosocial development of youth. However, there is an absence of observational measures to assess program quality related to psychosocial development ...
Corliss Bean, Sara Kramers, Martin Camiré, Jessica Fraser-Thomas, Tanya Forneris   +4 more
doaj   +1 more source

‘I guess it’s kind of elitist’: the formation and mobilisation of cultural, social and physical capital in youth sport volunteering [PDF]

, 2016
Policy and research portray sport volunteering as a means by which young people can develop skills and perform active citizenship. This paper draws on qualitative research with participants in a UK sport volunteering programme to critically examine young
Spaaij, Ramon, Storr, Ryan
core   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Psychosocial Aspects of Youth Disability Sport [PDF]

, 2006
Psychosocial aspects of participation in youth disability sport were examined using social-cognitive theory and the sport commitment model. An international sample of athletes with disabilities (N = 112) reported high levels of sport commitment and sport
Martin, Jeffrey J.
core   +2 more sources