Results 131 to 140 of about 1,295,685 (397)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Youth sport during the COVID-19 pandemic: The influence of race and affluence on parents’ perspectives of youth participation

Social Sciences and Humanities Open
COVID-19 restrictions led to a nearly 50% decline in youth sport participation across the United States (Dorsch et al., 2021). Today, communities and sport organizations have resumed sport.
Amand L. Hardiman, Daniel J.M. Fleming, Travis E. Dorsch, Jordan A. Blazo, Tom Farrey, Jennifer Brown Lerner, Jon Solomon   +6 more
doaj   +1 more source

Perceptions of parenting practices and psychological variables of elite and sub-elite youth athletes [PDF]

, 2019
Drawing from the model of parental involvement in sport, the overall purpose was to examine the associations of perceptions of parenting practices (encouragement, reinforcement, instruction, and role modeling) and athletes’ psychological variables (self ...
Calmeiro, Luis, Rosado, António, Serpa, Sidónio, Silva, Carlos, Teques, Pedro   +4 more
core   +4 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Significance of youth and sports in Ukraine backup for the education of the younger generation

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014
Purpose: determine the social significance and especially the development of youth and sports reserve in Ukraine. Material : a questionnaire survey of 50 experts in the sphere of physical culture and sports.
N. V. Tikhonova
doaj   +1 more source

YOUTH MOTIVES FOR PRACTICING SPORTS [PDF]

Exercise and Quality of Life, 2012
<p>The aim of this study is to determine the motivational structure of youths for practicing<br />sports. The research included 60 participants, of both sexes, all aged between 13 and 16. The<br />survey method was applied.
openaire   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

The effect of recreational fitness exercises on sedentary men’s levels of well-being [PDF]

Journal of Men's Health
Background: Recreation is an indispensable component of leisure time, and physical exercise is one of the most popular recreational activities among sedentary individuals.
Muhammet Eyüp Uzuner, Hakan Akdeniz, Müge Sarper, Mehmet Duman, Cengiz Aydin, Talha Altuntaş, Fikret Soyer   +6 more
doaj   +1 more source

The Effect of Single Sport Specialization in Youth Sports: A Prospective Cohort Study

, 2021
Richard E. Campbell, Danielle Weekes, Meghan Mattson, Fotios P. Tjoumakaris, Matthew D. Pepe, Bradford S. Tucker, Donghoon Lee   +6 more
openalex   +1 more source