Results 161 to 170 of about 846,283 (283)

Dual‐Array Nano Configuration for High‐Performance Metastable β Titanium Alloys

open access: yesAdvanced Science, EarlyView.
This work resolves a fundamental paradox in metastable alloys by establishing a novel dislocation‐phase coupling mechanism, enabling dynamic microstructure control for simultaneous thermal stability and deformability. Geometrically ordered α‐nanograins achieve unprecedented 500°C strength‐ductility synergy (863 MPa UTS, 78.3% elongation).
Tianle Li   +10 more
wiley   +1 more source

Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes. [PDF]

open access: yesNat Cardiovasc Res
Neo WH   +18 more
europepmc   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen   +16 more
wiley   +1 more source

HPV and HIV Among Youth: Exploring the Role of Knowledge, Risk Perception, and Attitude to Vaccination in Prevention Strategies. [PDF]

open access: yesVaccines (Basel)
Cocchio S   +7 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

open access: yesAdvanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen   +11 more
wiley   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

open access: yesAdvanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin   +6 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

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