Results 191 to 200 of about 1,061,367 (275)

MYC drives left-handed Z-DNA formation to shape gene expression. [PDF]

Nat Commun
Wan X, Fan H, Li Z, Du Y, Liu Y, Zeng W, Sun Z, Shao J, Jia J, Zhang Y, Fang D.   +10 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1^-/y mice. [PDF]

Nat Commun
Kornfeld-Sylla SS, Gelegen C, Norris JE, Chaloner FA, Lee M, Khela M, Heinrich MJ, Finnie PSB, Ethridge LE, Erickson CA, Schmitt LM, Cooke SF, Wilkinson CL, Bear MF.   +13 more
europepmc   +1 more source

Embedded Control of Z Source and Quasi-Z Source Based Multilevel Inverter

International Journal of ChemTech Research, 2018
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Reply to Comment on "Identification of Negative Ion at <i>m/z</i> 20 Produced by Atmospheric Pressure Corona Discharge Ionization under Ambient Air". [PDF]

Mass Spectrom (Tokyo)
Takayama M.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Scaling deep learning for material imaging with a pseudo 3D model for domain transfer. [PDF]

Nat Commun
Tang K, Armstrong RT, Mostaghimi P, Niu Y, Meyer Q, Zhao C, Finegan DP, Popeil M, Singh K, Menke H, Dimou AP, Bultreys T, Mascini A, Knackstedt M, Da Wang Y.   +14 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Valley-Dependent Topological Interface States in Biased Armchair Nanoribbons of Gapless Single-Layer Graphene for Transport Applications. [PDF]

Materials (Basel)
Huang ZH, Lai JY, Wu YS.
europepmc   +1 more source