Results 81 to 90 of about 160,250 (344)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

One-cycle control of switching converters [PDF]

open access: yes, 1995
A new large-signal nonlinear control technique is proposed to control the duty-ratio d of a switch such that in each cycle the average value of a switched variable of the switching converter is exactly equal to or proportional to the control reference in
Smedley, Keyue M., Ćuk, Slobodan
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Development of an intense positron source using a crystal--amorphous hybrid target for linear colliders

open access: yes, 2013
In a conventional positron source driven by a few GeV electron beam, a high amount of heat is loaded into a positron converter target to generate intense positrons required by linear colliders, and which would eventually damage the converter target.
Akagi, T.   +14 more
core   +3 more sources

A bremsstrahlung gamma-ray source based on stable ionization injection of electrons into a laser wakefield accelerator [PDF]

open access: yes, 2016
Laser wakefield acceleration permits the generation of ultra-short, high-brightness relativistic electron beams on a millimeter scale. While those features are of interest for many applications, the source remains constraint by the poor stability of the ...
Conejero, E.   +13 more
core   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

An Apparatus to Control and Monitor the Para-D2 Concentration in a Solid Deuterium, Superthermal Source of Ultra-cold Neutrons

open access: yes, 2003
Controlling and measuring the concentration of para-D2 is an essential step toward realizing solid deuterium as an intense ultra-cold neutron (UCN) source.
A. Saunders   +26 more
core   +1 more source

Voltage regulation considerations for the design of hybrid distribution transformers [PDF]

open access: yes, 2014
The future substation depends on finding a way to mitigate the effects of the drawbacks of the conventional legacy by employing the efficiency of the solid state switches [1].
Alqarni, M, Darwish, M, Radi, MA
core   +1 more source

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