Results 61 to 70 of about 11,168 (264)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Extended family of DC-DC Quasi-Z-Source converters

International Journal of Electrical and Computer Engineering (IJECE), 2019
The family of DC-DC q-ZSCs is extended from two to three classes and four to six members. All the members were analyzed based on efficient duty ratio range (R_Deff) and general duty ratio range (R_Dgen). Findings showed that similar to the traditional buck-boost converter (BBC), each of the topologies is ...
Ado, M., Jusoh, A., Sutikno, T.
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Design of Z source converter with the genetic-based chicken swarm algorithm for closed loop control of PV integrated grid

Automatika
A single-phase grid coupled PV system with a switched Z-source boost converter is analysed on the basis of closed-loop control using a novel hybrid algorithm.
R. Aandal, A. Ravi
doaj   +1 more source

Three-phase voltage-fed quasi-Z-source AC-AC converter

CES Transactions on Electrical Machines and Systems, 2018
The paper proposes a novel three-phase voltage-fed quasi-Z-source ac-ac converter topology to overcome the shortcomings of the traditional three-phase AC-AC chopper.
Xupeng Fang, Guanzhong Gao, Lixin Gao, Bolong Ma   +3 more
doaj   +1 more source

ANN-based dynamic control and energy management of inverter and battery in a grid-tied hybrid renewable power system fed through switched Z-source converter. [PDF]

Electr Eng (Berl), 2021
Santhoshi BK, Mohanasundaram K, Kumar LA.   +2 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Quasi‐Z‐source inverter with switched‐coupled‐capacitors

IET Power Electronics
This paper presents an improved switched‐inductor quasi‐Z‐source inverter with a higher boost factor than similar inverters, which integrates a switched‐capacitor and a three‐winding switched‐coupled inductor into a conventional quasi Z‐source inverter ...
Mohammad Hosein Babaei, Asghar Taheri, Jamal Abbasi Bolaghi, Masoumeh Gholami   +3 more
doaj   +1 more source