Results 61 to 70 of about 56,143 (293)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Stability and Frequency Regulation of Inverters with Capacitive Inertia [PDF]

, 2017
In this paper, we address the problem of stability and frequency regulation of a recently proposed inverter. In this type of inverter, the DC-side capacitor emulates the inertia of a synchronous generator.
De Persis, Claudio, Monshizadeh, Nima, Monshizadeh, Pooya, Stegink, Tjerk, van der Schaft, Arjan   +4 more
core   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

EMI Suppression of High-Frequency Isolated Quasi Z-Source Inverter Based on Multi-Scroll Chaotic PWM Modulation

IEEE Access, 2019
The high frequency isolated quasi Z-source inverter is a new type of inverter, which is suitable for photovoltaic generation system because of its high lift to voltage ratio, transient bridge direct access and electrical isolation.With the increase of ...
Yan Chen, Weihao Jiang, Yong Zheng, Guodongxu He   +3 more
doaj   +1 more source

A model predictive control strategy based on energy storage grid‐connected quasi‐z‐source inverters

IET Generation, Transmission & Distribution, 2022
The battery energy stored quasi‐Z‐source (BES‐qZS) based photovoltaic (PV) power generation system combines advantages of the qZS inverter and the battery energy storage (BES) system.
Lixiong Li, Tongguang Yang, Yueyang Yuan, Zhenhua Cai   +3 more
doaj   +1 more source

Comparison of different repetitive control architectures: synthesis and comparison. Application to VSI Converters [PDF]

, 2018
Repetitive control is one of the most used control approaches to deal with periodic references/disturbances. It owes its properties to the inclusion of an internal model in the controller that corresponds to a periodic signal generator.
Costa Castelló, Ramon, Ramos Fuentes, German A.   +1 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Quasi‐Z‐source inverter with switched‐coupled‐capacitors

IET Power Electronics
This paper presents an improved switched‐inductor quasi‐Z‐source inverter with a higher boost factor than similar inverters, which integrates a switched‐capacitor and a three‐winding switched‐coupled inductor into a conventional quasi Z‐source inverter ...
Mohammad Hosein Babaei, Asghar Taheri, Jamal Abbasi Bolaghi, Masoumeh Gholami   +3 more
doaj   +1 more source

Series-type switched-inductor Z-source inverter

CES Transactions on Electrical Machines and Systems, 2020
To solve the disadvantages of the traditional Z-source inverter (ZSI), this paper investigates a series-type switched-inductor Z-source inverter (SSI-ZSI) topology.
Xupeng Fang, Yingying Tian, Xiaokang Ding, Bolong Ma   +3 more
doaj   +1 more source