Results 51 to 60 of about 164,290 (263)

YATL:Yet Another Transformation Language [PDF]

, 2004
With the increased use of modelling techniques has come the desire to use model transformations. Model transformations systems are graph transformations systems that perform translations between languages defined by a corresponding metamodel. The current
Patrascoiu, Octavian
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Parallel Graph Transformation for Model Simulation applied to Timed Transition Petri Nets [PDF]

, 2004
Proceedings of the Workshop on Graph Transformation and Visual Modelling Techniques (GT-VMT 2004)This work discusses the use of parallel graph transformation systems for (multi-formalism) modeling and simulation and their implementation in the meta ...
Taentzer, Gabriele, Ehrig, Karsten, Ermel, Claudia, Ermel, C., Ehrig, K., Taentzer, G., Lara Jaramillo, Juan de, de Lara, J.   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Weak Dynkin type and the universality of non-negative Coxeter-regular integral quadratic forms

Documenta Mathematica
An integral quadratic form is called Coxeter-regular if its integer coefficients satisfy a divisibility condition equivalent to the fact that the associated Coxeter transformation and Weyl group are integral.
Andrzej Mróz, K. Zając
semanticscholar   +1 more source

Ten virtues of structured graphs

, 2009
This paper extends the invited talk by the first author about the virtues of structured graphs. The motivation behind the talk and this paper relies on our experience on the development of ADR, a formal approach for the design of styleconformant ...
Lluch-Lafuente, Alberto, LLUCH LAFUENTE A., Lluch Lafuente, Alberto, Bruni, Roberto   +3 more
core   +1 more source

Mapping EDOC to Web Services using YATL [PDF]

, 2004
Modeling is a technique used extensively in industry to define software systems, the UML being the most prominent example. With the increased use of modeling techniques has come the desire to use model transformations.
Patrascoiu, Octavian
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source