Results 121 to 130 of about 3,719,554 (276)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Perspective on solving the problem of declining interest in physical activity in Poland
Frontiers in Sports and Active LivingOne of the leading areas of Polish research addressed in the physical culture sciences, is the declining interest in physical activity. The likely reason for this situation may be the inadequate communication of physical culture to today's generations ...
Paweł Adam Piepiora +2 more
doaj +1 more source
Strategic Perspectives on Business and Marketing Managementวัตถุประสงค์ - งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาอิทธิพลของคุณภาพการให้บริการของพนักงานขาย ที่มีต่อความไว้วางใจในตราสินค้าและความตั้งใจซื้อผลิตภัณฑ์ไอทีของผู้บริโภคกลุ่ม Generation Z โดยพิจารณาจากคุณภาพการให้บริการ 5 ด้าน ดังนี้ การตอบสนองต่อผู้บริโภค (Responsiveness) การให้ความเชื่อมั่นกับผู้บริโภค (Assurance) ความน่าเชื่อถือไว้วางใจ (Reliability ...
openaire +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
JPFT (Jurnal Pendidikan Fisika dan Teknologi)Generation Z, growing up in an era of constantly evolving technology and information, presents new challenges for the world of education. They are known as a digitally connected generation, quick to adapt to technological advancements, and in search of ...
Iftitah Imawati +2 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Commitment of Generation Z Employees – Diagnosis, Expectations, and Courses of Action
Prace Naukowe Uniwersytetu Ekonomicznego we WrocławiuAim: The aim of the article was to determine the level of engagement of Generation Z and to indicate directions for actions aimed at consciously shaping it within the organisation. Methodology: A literature review and analysis of the results of a survey
Magdalena Borowska +1 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source