Results 11 to 20 of about 725 (155)

The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis

FEBS Letters, Volume 597, Issue 12, Page 1623-1637, June 2023., 2023
Using single‐cell RNA‐seq and super‐resolution microscopy from several multiciliogenesis models, we show that BTG4, LAYN, and HOATZ, three proximal genes of the MIR34B/C locus, are expressed in precursors and mature multiciliated cells (MCCs). This graphical abstract illustrates the localization of Layilin/LAYN and HOATZ in motile cilia of MCCs.
Amélie Cavard, Elisa Redman, Olivier Mercey, Sophie Abelanet, Magali Plaisant, Marie‐Jeanne Arguel, Virginie Magnone, Sandra Ruiz García, Géraldine Rios, Marie Deprez, Kévin Lebrigand, Gilles Ponzio, Ignacio Caballero, Pascal Barbry, Laure‐Emmanuelle Zaragosi, Brice Marcet   +15 more
wiley   +1 more source

Perceived barriers and facilitators to health behaviors in European childhood cancer survivors: A qualitative PanCareFollowUp study

Cancer Medicine, Volume 12, Issue 11, Page 12749-12764, June 2023., 2023
Abstract Background Healthy behaviors, that is, engaging in regular physical activities, maintaining a healthy diet, limiting alcohol consumption, and avoiding tobacco and drug use, decrease the risk of developing late adverse health conditions in childhood cancer survivors.
Eline Bouwman, Saskia M. F. Pluijm, Iridi Stollman, Vera Araujo‐Soares, Nicole M. A. Blijlevens, Cecilia Follin, Jeanette F. Winther, Lars Hjorth, Tomas Kepak, Katerina Kepakova, Leontien C. M. Kremer, Monica Muraca, Helena J. H. van der Pal, Carina Schneider, Anne Uyttebroeck, Gertrui Vercruysse, Rod Skinner, Morven C. Brown, Rosella P. M. G. Hermens, Jacqueline J. Loonen, the PanCareFollowUp Consortium   +20 more
wiley   +1 more source

ASPRE trial: effects of aspirin on mean arterial blood pressure and uterine artery pulsatility index trajectories in pregnancy

Ultrasound in Obstetrics &Gynecology, Volume 61, Issue 6, Page 691-697, June 2023., 2023
ABSTRACT Objectives The mechanism by which aspirin prevents pre‐eclampsia is poorly understood, and its effects on biomarkers throughout pregnancy are unknown. We aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA‐PI) using repeated measures from women at increased risk of preterm ...
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides   +5 more
wiley   +1 more source

Reactive oxygen species in status epilepticus

Epilepsia Open, Volume 8, Issue S1, Page S66-S72, May 2023., 2023
Abstract It has long been recognized that status epilepticus can cause considerable neuronal damage, and this has become one of its defining features. The mechanisms underlying this damage are less clear. Excessive activation of NMDA receptors results in large rises in internal calcium, which eventually lead to neuronal death.
Matthew C Walker
wiley   +1 more source

Risk prediction of atrial fibrillation and its complications in the community using hs troponin I

European Journal of Clinical Investigation, Volume 53, Issue 5, May 2023., 2023
Abstract Aims Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood‐based biomarkers reflecting cardiac injury such as high‐sensitivity troponin I (hsTnI) may help close this gap.
Christin S. Börschel, Bastiaan Geelhoed, Teemu Niiranen, Stephan Camen, Maria Benedetta Donati, Aki S. Havulinna, Francesco Gianfagna, Tarja Palosaari, Pekka Jousilahti, Jukka Kontto, Erkki Vartiainen, Francisco M. Ojeda, Hester M. den Ruijter, Simona Costanzo, Giovanni de Gaetano, Augusto Di Castelnuovo, Allan Linneberg, Julie K. Vishram‐Nielsen, Maja‐Lisa Løchen, Wolfgang Koenig, Torben Jørgensen, Kari Kuulasmaa, Stefan Blankenberg, Licia Iacoviello, Tanja Zeller, Stefan Söderberg, Veikko Salomaa, Renate B. Schnabel   +27 more
wiley   +1 more source

Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

Movement Disorders, Volume 38, Issue 4, Page 604-615, April 2023., 2023
Abstract Background Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective We used results from genome‐wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify ...
Pierre‐Emmanuel Sugier, Elise A. Lucotte, Cloé Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq‐Daian, Anne Boland‐Augé, Robert Olaso, Jean‐françois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guénel, on behalf of the EPITHYR consortium, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov‐Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean‐Christophe Corvol, Marie‐Christine Chartier‐Harlin, Eugénie Mutez, Kathrin Brockmann, Angela B. Deutschländer, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P.C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrøm, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez‐Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Rödström, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, on behalf of the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage‐PD) consortium, Thérèse Truong, Alexis Elbaz   +95 more
wiley   +1 more source

An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup

Pharmacology Research &Perspectives, Volume 11, Issue 1, February 2023., 2023
Time profile of plasma ethosuximide concentrations according to formulation. Abstract Ethosuximide, the first‐line therapy for childhood absence epilepsy, is currently formulated as a syrup (Zarontin®, Pfizer) with a bitter taste and high sugar content, poorly adapted to children, and a ketogenic diet.
Léonore Diezi, Kim Dao, Vincent Jullien, Caroline Roussel‐Maupetit, Ingrid Burton, Pascal André, Carine Bardinet, Laura E. Rothuizen, Haithem Chtioui, Maria A. Manso‐Silvan, Catherine Guittet, Françoise Brunner‐Ferber, Francois Vandenhende, Catherine Chiron, Luc‐André Granier, Thierry Buclin   +15 more
wiley   +1 more source

Phase‐based masking for quantitative susceptibility mapping of the human brain at 9.4T

Magnetic Resonance in Medicine, Volume 88, Issue 5, Page 2267-2276, November 2022., 2022
Purpose To develop improved tissue masks for QSM. Methods Masks including voxels at the brain surface were automatically generated from the magnitude alone (MM) or combined with test functions from the first (PG) or second (PB) derivative of the sign of the wrapped phase.
Gisela E. Hagberg, Korbinian Eckstein, Elisa Tuzzi, Jiazheng Zhou, Simon Robinson, Klaus Scheffler   +5 more
wiley   +1 more source

Who is vulnerable to energy poverty in the Global North, and what is their experience?

WIREs Energy and Environment, Volume 11, Issue 6, November/December 2022., 2022
The image depicts a single‐parent, mother‐led family from an ethnic minority background watching TV in bed in the evenings to keep warm without the heating on, to represent some of the experiences and backgrounds of the energy poor. Note: Artwork by Mary Tallontire @marytallontire Abstract Energy poverty is a fast rising government agenda in the Global
Lucie Middlemiss
wiley   +1 more source

Recovery of Bone Marrow Function in VEXAS Syndrome‐potential Role for Romiplostim

, 2023
HemaSphere, Volume 7, Issue 8, August 2023.
Adam Al‐Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James Poulter, David G. Kent, Sinisa Savic, on behalf of the ImmunAID consortium   +12 more
wiley   +1 more source