Results 71 to 80 of about 101,248 (263)

Phylogeny and distribution of protein kinase C variants in the zebrafish [PDF]

Journal of Comparative Neurology, 2018
AbstractConventional protein kinases—consisting of α, β, and γ family members—play key roles in numerous signal transduction events. Phylogenetic analysis demonstrated the existence of five prkcs (the genes representing PKCs) in zebrafish, two paralogous forms of prkca and prkcb and one prkcg variant.
Haug, Marion F, Gesemann, Matthias, Berger, Manuela, Neuhauss, Stephan C F   +3 more
openaire   +3 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Quantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during the maternal-to-zygotic transition

iScience
Summary: Maternal-to-zygotic transition (MZT) is central to early embryogenesis. However, its underlying molecular mechanisms are still not well described.
Fei Fang, Daoyang Chen, Abdul Rehman Basharat, William Poulos, Qianyi Wang, Jose B. Cibelli, Xiaowen Liu, Liangliang Sun   +7 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Zebrafish Trak proteins 1a and 2 localize to the mitochondria

microPublication biology, 2020
Inside a cell, mitochondria are organelles that exhibit dynamic locomotion and spatial rearrangement (Cai and Sheng 2009; Sheng 2017). This movement is necessary for a cell to maintain basic metabolic functions, and disruption of this motility often results in cell death.
Oonk, Kelsey A, Bienvenu, Lauren B, Sickler, Paxton S, Martin, Christine, Nickoloff-Bybel, Emily, Volk, Albert Matthew, Weiser, Douglas C, Walsh, Susan   +7 more
openaire   +2 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Therapeutic Potential of DPHC, A Brown Seaweed Polyphenol, Against TNF-α-Induced Inflammatory Muscle Loss

Marine Drugs
Inflammatory muscle loss results from excessive inflammatory responses, causing muscle damage and weakness. In the current investigation, we evaluated the protective effects of diphlorethohydroxycarmalol (DPHC) against tumor necrosis factor-alpha (TNF-α)-
Minji Kim, Won-Woo Lee, Kil-Nam Kim, Young-Mog Kim, You-Jin Jeon, Fengqi Yang, Seo-Young Kim, Hyo-Geun Lee   +7 more
doaj   +1 more source

Optogenetic control of transcription in zebrafish.

PLoS ONE, 2012
Light inducible protein-protein interactions are powerful tools to manipulate biological processes. Genetically encoded light-gated proteins for controlling precise cellular behavior are a new and promising technology, called optogenetics.
Hongtao Liu, Gustavo Gomez, Sophia Lin, Shuo Lin, Chentao Lin   +4 more
doaj   +1 more source

Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish

PLoS Biology, 2004
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or gross evidence of tumors. We identified 12 lines with elevated cancer incidence.
Amsterdam, A, Sadler, K C, Lai, K, Farrington, S, Bronson, R T, Lees, J A, Hopkins, N   +6 more
openaire   +4 more sources

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source