Results 71 to 80 of about 107,862 (214)

Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish

PLoS Biology, 2004
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or gross evidence of tumors. We identified 12 lines with elevated cancer incidence.
Amsterdam, A, Sadler, K C, Lai, K, Farrington, S, Bronson, R T, Lees, J A, Hopkins, N   +6 more
openaire   +4 more sources

Quantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during the maternal-to-zygotic transition

iScience
Summary: Maternal-to-zygotic transition (MZT) is central to early embryogenesis. However, its underlying molecular mechanisms are still not well described.
Fei Fang, Daoyang Chen, Abdul Rehman Basharat, William Poulos, Qianyi Wang, Jose B. Cibelli, Xiaowen Liu, Liangliang Sun   +7 more
doaj   +1 more source

Ribosomal proteins in zebrafish haematopoiesis and human disease

, 2011
PhDSeveral congenital disorders of human haematopoiesis including Diamond- Blackfan anaemia result from heterozygous loss of genes involved in ribosome biogenesis.
Payne, Elspeth
core  

Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain

, 2019
Brazilian National Research CouncilFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Brazilian National Research Council: 449390/2014-4Processo FAPESP: 2015/22752-0Processo FAPESP: 2016/04000-3Processo FAPESP: 2013/07467-0Peptides represent a ...
Correa, Claudia Neves, Manzi Teixeira, Caio Matheus [UNESP], Manzi Teixeira, Caio Matheus, Correa, Claudia Neves [UNESP], Iwai, Leo Kei, Castro, Leandro Mantovani de, Castro, Leandro Mantovani de [UNESP], Ferro, Emer Suavinho   +7 more
core   +1 more source

Therapeutic Potential of DPHC, A Brown Seaweed Polyphenol, Against TNF-α-Induced Inflammatory Muscle Loss

Marine Drugs
Inflammatory muscle loss results from excessive inflammatory responses, causing muscle damage and weakness. In the current investigation, we evaluated the protective effects of diphlorethohydroxycarmalol (DPHC) against tumor necrosis factor-alpha (TNF-α)-
Minji Kim, Won-Woo Lee, Kil-Nam Kim, Young-Mog Kim, You-Jin Jeon, Fengqi Yang, Seo-Young Kim, Hyo-Geun Lee   +7 more
doaj   +1 more source

Optogenetic control of transcription in zebrafish.

PLoS ONE, 2012
Light inducible protein-protein interactions are powerful tools to manipulate biological processes. Genetically encoded light-gated proteins for controlling precise cellular behavior are a new and promising technology, called optogenetics.
Hongtao Liu, Gustavo Gomez, Sophia Lin, Shuo Lin, Chentao Lin   +4 more
doaj   +1 more source

Commissural Axon Kinetics and the Role of Netrin in Early Brain Circuitry Development [PDF]

, 2005
As neurons begin to differentiate, they send out processes called axons to initiate the formation of functional nerve connections. A specialized structure at the end of an axon called the growth cone is believed to possess the impressive navigational and
Bak-Maier, Magdalena
core   +1 more source

Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity.

PLoS ONE, 2011
Neuroglobin (Ngb) is a recently discovered vertebrate globin that is expressed in the brain and can reversibly bind oxygen. Mammalian Ngb is involved in neuroprotection during oxidative stress that occurs, for example, during ischemia and reperfusion ...
Seiji Watanabe, Keisuke Wakasugi
doaj   +1 more source

Zebrafish Trak proteins 1a and 2 localize to the mitochondria

microPublication biology, 2020
Inside a cell, mitochondria are organelles that exhibit dynamic locomotion and spatial rearrangement (Cai and Sheng 2009; Sheng 2017). This movement is necessary for a cell to maintain basic metabolic functions, and disruption of this motility often results in cell death.
Oonk, Kelsey A, Bienvenu, Lauren B, Sickler, Paxton S, Martin, Christine, Nickoloff-Bybel, Emily, Volk, Albert Matthew, Weiser, Douglas C, Walsh, Susan   +7 more
openaire   +2 more sources

Editorial: Zebrafish Models for Human Disease Studies

, 2022
Zebrafish are an attractive vertebrate model organism for biomedical discovery (Tavares and Santos Lopes, 2013). The advantages of using zebrafish are well known and include cost-effectiveness, high fecundity, short generation time, external development,
Shimada, Y., Torraca, V., Zang, L., Nishimura, N.   +3 more
core   +1 more source