Results 91 to 100 of about 265,688 (306)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Design of a new type of integrated test bench for mine-used high-voltage protector

Gong-kuang zidonghua, 2016
A new type of integrated test bench for mine-used high-voltage protector was designed. The overall structure and design schemes of software and hardware of the test bench were introduced.
HUANG Hesong, BI Zhongsi, XUE Lin, ZHANG Xiangyang   +3 more
doaj   +1 more source

Penentration of dynamic localized states in DC-driven Josephson junction ladders by discrete jumps

, 2001
We give a theoretical study of unusual resistive (dynamic) localized states in anisotropic Josephson junction ladders, driven by a DC current at one edge.
A. Barone, A. J. Sievers, B.I. Swanson, D. Abraimov, D. Bonart, E. Trias, G. Grimaldi, J. B. Page, K.K. Likharev, M. V. Fistul, M.P. Allen, P. Binder, P. Binder, P. Caputo, S. Flach, S.H. Strogatz, U.T. Schwarz   +16 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Circulating Current Suppression and Midpoint Potential Balance of Flexible DC T-Type Three-Level Bidirectional Converter for Urban Rail Transit [PDF]

Dianli jianshe
[Objective] A bidirectional converter integrates traction， feedback， and reactive power compensation and is the primary choice for upgrading the main equipment of an urban rail DC traction power supply system.
LIU Jianhua, LI Dongdong, LI Hao
doaj   +1 more source

Power Flow Control and Current Ripple Minimization of HVDC Converter System by Using Zero-Sequence Voltage Injection Control [PDF]

, 2016
This paper introduces the Zero_Sequence Voltage_Injection(ZSVI) based Model Predictive_Control (MPC) to minimize the ripples in dc current & voltage and concurrently regulate the power_flow & dc_current. This paper takes the benefits to calculate
B, R. I. (Rekha), R, P. S. (Prof)
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Design of Selective Leakage Protection Circuit Based on Method of Amplitude Discrimination and Phase Discriminatio

Gong-kuang zidonghua, 2010
The paper proposed a design scheme of selective leakage protection circuit based on method of amplitude discrimination and phase discrimination for electrical control equipments of fully mechanized devices of coal mine underground.The selective leakage ...
FAN Yi-long~, LI Hang~, YOU Guo-dong~
doaj