Results 51 to 60 of about 419,100 (266)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Zero (Total) Forcing Number and Covering Number of Trees

open access: yesTaiwanese Journal of Mathematics
Summary: Let \(F(G)\), \(F_t (G)\), \(\beta (G)\), and \(\beta^\prime(G)\) be the zero forcing number, the total forcing number, the vertex covering number and the edge covering number of a graph \(G\), respectively. In this paper, we first completely characterize all trees \(T\) with \(F(T) = (\Delta -2) \beta (T)+1\), solving a problem proposed by ...
Tu, Dongxin, Li, Jianxi, Shiu, Wai-Chee
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Achievable Rates for Full-Duplex Massive MIMO Systems Over Rician Fading Channels

open access: yesIEEE Access, 2018
We study the uplink and downlink achievable rate of full-duplex large-scale multi-input multioutput (MIMO) systems with a base station (BS) and users over Rician fading channels, based on maximum ratio combining/maximum ratio transmission and zero ...
Juan Liu   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

0034 | Zero Forcing Number in Neutrosophic Graphs

open access: yes, 2022
In this book, some notions are introduced about Zero Forcing Number in Neutrosophic Graphs. Three chapters are devised as Common Notions , Modified Notions and Extended Notions . Three manuscripts are cited as the references of these chapters which are my 47th, 48th, and 49th manuscripts.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A Comparison between the Metric Dimension and Zero Forcing Number of Trees and Unicyclic Graphs

open access: yes, 2017
The \emph{metric dimension} $\dim(G)$ of a graph $G$ is the minimum number of vertices such that every vertex of $G$ is uniquely determined by its vector of distances to the chosen vertices.
Eroh, Linda, Kang, Cong X., Yi, Eunjeong
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Upper bounds on the k-forcing number of a graph [PDF]

open access: yes, 2014
Given a simple undirected graph $G$ and a positive integer $k$, the $k$-forcing number of $G$, denoted $F_k(G)$, is the minimum number of vertices that need to be initially colored so that all vertices eventually become colored during the discrete ...
Amos, David   +3 more
core  

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