Results 31 to 40 of about 3,675,881 (280)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Application of Data Security Models in Zero - Trust Architecture from the Data Assets Perspectives

Diversitas Journal
Today, data assets have become the core assets of enterprises and organizations, and their security is of utmost importance. The traditional network security architecture has revealed many limitations in protecting data assets, giving rise to the zero -
Fangshu Hu, Jessa Frida Festijo
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Zero Trust Container Architecture (ZTCA)

International Conference on Cyber Warfare and Security, 2022
Containerisation is quickly becoming an accepted industry standard for development environments and Gartner, in a recent market forecast, estimated that by 2022 more than 75% of organisations will be using containers in production deployments. With this explosion in growth comes an added focus on security and best practices for using containers.
Darragh Leahy, Christina Thorpe
openaire   +2 more sources

Research on security protection of unmanned aerial vehicle systems based on zero trust

Dianzi Jishu Yingyong
In recent years, unmanned aerial vehicles (UAVs) have been widely used in the military and civilian fields, especially since the Russia-Ukraine conflict, their advantages of low cost and strong functions are particularly prominent and have played a huge ...
Ji Shengkai, Yang Zhiming, Zhao Jiankun, Li Bin, Huang Yilong   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Toward zero trust in 5G Industrial Internet collaboration systems

Digital Communications and Networks
With the introduction of 5G, users and devices can access the industrial network from anywhere in the world. Therefore, traditional perimeter-based security technologies for industrial networks can no longer work well.
Han Zhang, Ziyan Zhang, Liquan Chen
doaj   +1 more source

Zero Trust Architecture: A Comprehensive Approach to Incident Response Management [PDF]

Zero Trust Architecture is a modern security strategy that is based on the principle of “never trust, always verify”. This approach to security eliminates trust from an organization’s network architecture and focuses on managing enterprise risk ...
Wiryana, I Made, Satria, Muhamad Zein, Rimbawa, H.A Danang   +2 more
core   +1 more source