Results 81 to 90 of about 34,515 (266)

La hipòtesi de Riemann: El gran repte pendent

Mètode Science Studies Journal: Annual Review, 2018
La hipòtesi de Riemann és una afirmació, no demostrada, que fa referència als zeros de la funció zeta de Riemann. Bernhard Riemann calculà els sis primers zeros no trivials d’aquesta funció i observà que tots estaven sobre una mateixa recta.
Pilar Bayer
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

On Polynomials Associated with Finite Topologies

Axioms
Let τ be a topology on the finite set Xn. We consider the open-set polynomial associated with the topology τ. Its coefficients are the cardinalities of sets Uj=Uj(τ) of open sets of size j=0,…,n.
Moussa Benoumhani, Brahim Chaourar
doaj   +1 more source

Improving the Asymptotic Properties of Discrete System Zeros in Fractional-Order Hold Case

Journal of Applied Mathematics, 2013
Remarkable improvements in the asymptotic properties of discrete system zeros may be achieved by properly adjusted fractional-order hold (FROH) circuit.
Cheng Zeng, Shan Liang, Yingying Su
doaj   +1 more source

On the Zeros of Polynomials

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1977
1. Govil and Rahman [1, Theorem 1] have proved the fol- lowing theorem.n Theorem A. Let p (z) = £ aj^ k“0 z’^ ( 0) be a polynomiai ofdegree n with complex coefficients such that for some a>«-1 I a^ •11-2 a' I »ol-Then p (z) has ali its zeros in |z Kj, where Kj is the greatest positive root of the trinomial equation K"+ı - 2K" + 1 =
openaire   +4 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source