Results 101 to 110 of about 658,068 (316)

Interferon lambda protects the female reproductive tract against Zika virus infection

Nature Communications, 2019
Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are not well characterized.
Elizabeth A. Caine, S. Scheaffer, N. Arora, Konstantin Zaitsev, M. Artyomov, C. Coyne, K. Moley, M. Diamond   +7 more
semanticscholar   +1 more source

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection

Science Advances, 2020
IL-27 signaling activates the production of antiviral proteins in the skin and inhibits Zika virus infection. In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense.
J. Kwock, C. Handfield, J. Suwanpradid, P. Hoang, M. J. McFadden, Kevin Labagnara, L. Floyd, J. Shannon, R. Uppala, M. Sarkar, J. Gudjonsson, D. Corcoran, Helen M. Lazear, G. Sempowski, Stacy M. Horner, A. MacLeod   +15 more
semanticscholar   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Zika virus infection [PDF]

Radiologia Brasileira, 2019
Orcun Barkay, Faruk Karakeçili
openaire   +4 more sources

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

Cell Reports, 2017
Zika virus is an emerging arthropod-borne flavivirus for which there are no vaccines or specific therapeutics. We screened a library of 2,000 bioactive compounds for their ability to block Zika virus infection in three distinct cell types with two ...
Keiko Rausch, Brent A. Hackett, Nathan L. Weinbren, Sophia M. Reeder, Yoel Sadovsky, Christopher A. Hunter, David C. Schultz, Carolyn B. Coyne, Sara Cherry   +8 more
doaj   +1 more source

Detailed Analyses of Zika Virus Tropism in Culex quinquefasciatus Reveal Systemic Refractoriness

mBio, 2020
The role of Culex quinquefasciatus in Zika virus transmission has been debated since the epidemic of Zika occurred in the Americas in 2015 to 2016. The majority of studies have found no evidence that C.
Hannah J. MacLeod, George Dimopoulos
doaj   +1 more source

Description of 13 Infants Born During October 2015-January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth - Brazil.

MMWR. Morbidity and mortality weekly report, 2016
Congenital Zika virus infection can cause microcephaly and severe brain abnormalities (1). Congenital Zika syndrome comprises a spectrum of clinical features (2); however, as is the case with most newly recognized teratogens, the earliest documented ...
V. van der Linden, A. Pessoa, W. Dobyns, A. J. Barkovich, Hélio van der Linden Júnior, Epitacio Leite Rolim Filho, Erlane Marques Ribeiro, Mariana de Carvalho Leal, Pablo Picasso de Araújo Coimbra, Maria de Fátima Viana Vasco Aragão, I. Verçosa, C. Ventura, R. Ramos, Danielle Di Cavalcanti Sousa Cruz, Marli Tenório Cordeiro, V. Mota, Mary M Dott, Christina L. Hillard, Cynthia A. Moore   +18 more
semanticscholar   +1 more source

The inoculum dose of Zika virus can affect the viral replication dynamics, cytokine responses and survival rate in immunocompromised AG129 mice

Molecular Biomedicine
Zika virus, a mosquito-borne arbovirus, has repeatedly caused large pandemics with symptoms worsening from mild and self-limiting diseases to Guillain–Barré syndrome in adults and fetal microcephaly in newborns.
Yuhuan Yan, Hao Yang, Yun Yang, Junbin Wang, Yanan Zhou, Cong Tang, Bai Li, Qing Huang, Ran An, Xiaoming Liang, Dongdong Lin, Wenhai Yu, Changfa Fan, Shuaiyao Lu   +13 more
doaj   +1 more source

Zika Virus–Associated Cognitive Impairment in Adolescent, 2016

Emerging Infectious Diseases, 2017
Incidence of neurologic manifestations associated with Zika virus infection has been increasing. In 2016, neuropsychological and cognitive changes developed in an adolescent after travel to a Zika virus–endemic area.
Jason Zucker, Natalie Neu, Claudia A. Chiriboga, Veronica J. Hinton, Marc Leonardo, Arif Sheikh, Kiran Thakur   +6 more
doaj   +1 more source

Some Models for Epidemics of Vector-Transmitted Diseases [PDF]

arXiv, 2016
Vector-transmitted diseases such as dengue fever and chikungunya have been spreading rapidly in many parts of the world. The Zika virus has been known since 1947 and invaded South America in 2013. It can be transmitted not only by (mosquito) vectors but also directly through sexual contact.
arxiv