Results 71 to 80 of about 12,603 (200)
The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model [PDF]
, 2013 Objective: Antipsychotic drugs are known to have strongeffect on the bioelectric activity in the brain. However,some studies addressing the changes on electroencephalography(EEG) caused by typical and atypical antipsychoticdrugs are conflicting. We aimed
Mustafa Yılmaz, Oytun Erbaş
core +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Lurasidone for the treatment of bipolar depression: an evidence-based review [PDF]
, 2015 Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients’ lives as well as health care systems around the world.
Corse, Andrew +4 more
core +1 more source
International Journal of Mental Health Nursing, Volume 35, Issue 1, February 2026.ABSTRACT Minimising formal coercion, such as seclusion, physical restraint, and forced medication, remains a global priority in acute mental health units. However, key drivers beyond individual‐level features are poorly understood. This exploratory analysis was intended to identify the top functional, contextual, and interventional features linked to ...
Esario IV Daguman +3 more
wiley +1 more source
Antipsychotic Response in the First Week Predicts Later Efficacy [PDF]
, 2012 Background and Aims: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response.
Andrisano, Costanza +7 more
core +1 more source
Psychiatry and Clinical Neurosciences, Volume 80, Issue 1, Page 64-75, January 2026.Aim Artificial Intelligence (AI)‐based prediction models of treatment response promise to revolutionize psychiatric care by enabling personalized treatment, but very few have been thoroughly tested in different samples or compared to current clinical standards.
Fiona Coutts +10 more
wiley +1 more source
Psychovegetative syndrome: challenges in diagnosis and effective treatment
Медицинский совет, 2019 Autonomic dysfunction syndrome (ADS) includes the somatic (autonomic) function disorders of various origin and manifestations caused by their neurogenic regulation disorder.
О. V. Kotova +2 more
doaj +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.Purpose This study aimed to identify high‐risk drugs for drug‐induced extrapyramidal disorder (EPD) and explore their molecular mechanisms by integrating pharmacovigilance analytics with genetic and computational approaches. Methods We performed disproportionality analysis on FAERS data (2004–2024) to detect EPD signals, time‐to‐onset analysis to ...
Hao Wen +3 more
wiley +1 more source
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat [PDF]
, 2009 YesRationale: 5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. Aim: To investigate the involvement of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in female rats, a task
McLean, Samantha L. +3 more
core +1 more source
A Case of Pegfilgrastim‐Induced Sweet Syndrome and Literature Review of Similar Cases
Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.Sweet′s syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare disorder characterized by painful erythematous lesions, fever, and neutrophilic dermal infiltrates. Drug‐induced Sweet′s syndrome (DISS) is most often associated with short‐acting granulocyte colony‐stimulating factors (G‐CSF), whereas pegfilgrastim, the long‐acting ...
Meghana Kesireddy +4 more
wiley +1 more source