Results 1 to 10 of about 58,537 (229)

Early risperidone exposure impairs cognitive function by perturbation of the gut microbiome and bile acids/tyrosine-PTP1B axis [PDF]

Microbiome
Background Second-generation antipsychotics (SGAs) are increasingly being utilized in children and adolescents. Risperidone, one of the most commonly prescribed SGAs in this population, has been found to adversely affect cognitive function; however ...
Huaiyu Ye, Xiaoying Yang, Mingxuan Zheng, Wei Dong, Xi Chen, Jiajia Chen, Minmin Hu, Menglu Zhou, Peng Zheng, Lijun Shen, Yuqing Wu, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu   +13 more
doaj   +2 more sources

Analysis of Pharmacokinetic and Pharmacodynamic Interactions Between Chlorpromazine and Risperidone via Simultaneous Measurement of Multiple Receptor Occupancy in the Rat Brain [PDF]

Biomedicines
Background/Objectives: Combination therapy for schizophrenia may exacerbate side effects mediated by multiple brain receptors. This study aimed to elucidate the pharmacodynamic and pharmacokinetic interactions between chlorpromazine and risperidone.
Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Takashi Okura   +3 more
doaj   +2 more sources

Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure

EBioMedicine, 2015
Risperidone is a second-generation antipsychotic that causes weight gain. We hypothesized that risperidone-induced shifts in the gut microbiome are mechanistically involved in its metabolic consequences.
Justin L Grobe,, Faha, Faps, John R Kirby   +1 more
exaly   +3 more sources

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

Brain and Behavior, 2023
Background Previous studies suggest the possible effect of risperidone on brain reward system and D1 and D2 dopamine receptors’ involvement in morphine‐induced conditioned place preference (CPP).
Zahra Mansouri Arani, Nasrin Heidariyeh, Gholamreza Ghavipanjeh, Majid Lotfinia, Hamid Reza Banafshe   +4 more
doaj   +1 more source

Risperidone: Stuttering [PDF]

Hospital Pharmacy, 2014
This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a publication available from Wolters Kluwer Health. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. This new guide to the literature enables the health care professional or
Joyce A, Generali, Dennis J, Cada
openaire   +2 more sources

Housing Temperature Influences Atypical Antipsychotic Drug‐Induced Bone Loss in Female C57BL/6J Mice

JBMR Plus, 2021
Atypical antipsychotic (AA) drugs, such as risperidone, are associated with endocrine and metabolic side effects, including impaired bone mineral density (BMD) acquisition and increased fracture risk. We have previously shown that risperidone causes bone
Roni F Kunst, Audrie L Langlais, Deborah Barlow, Karen L Houseknecht, Katherine J Motyl   +4 more
doaj   +1 more source

External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data

Frontiers in Pharmacology, 2022
Risperidone is approved to treat schizophrenia in adolescents and autistic disorder and bipolar mania in children and adolescents. It is also used off-label in younger children for various psychiatric disorders.
Eleni Karatza, Samit Ganguly, Samit Ganguly, Chi D. Hornik, William J. Muller, Amira Al-Uzri, Laura James, Stephen J. Balevic, Daniel Gonzalez   +8 more
doaj   +1 more source

Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone

Scientific Reports, 2021
Recently, the Clinical Pharmacogenetics Implementation Consortium (CPIC) have revised recommendations for the translation of CYP2D6 genotype to phenotype.
Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem   +6 more
doaj   +1 more source

Terbinafine and risperidone drug interaction contributing to clinical changes in a forensic psychiatric patient [PDF]

Mental Health Clinician, 2023
Risperidone is a second generation “atypical” antipsychotic that exhibits its clinical effects through a combined effort of risperidone and its active metabolite, 9-hydroxyrisperidone (9-OHR), otherwise known as paliperidone.
Reynolds Jamie PharmD, Gramlich Nicole PharmD, BCPP   +1 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film

Frontiers in Pharmacology, 2020
ObjectiveThe aim of the present study was to investigate the absorption routes as well as the potential application of the oral transmucosal delivery of risperidone orodispersible film (ODF) using physiologically based pharmacokinetic modeling.MethodsThe
Fang Chen, Hongrui Liu, Bing Wang, Liuliu Yang, Weimin Cai, Zheng Jiao, Zhou Yang, Yusheng Chen, Yingjun Quan, Xiaoqiang Xiang, Hao Wang   +10 more
doaj   +1 more source