Results 171 to 180 of about 13,894 (263)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Protocol for isolating and culturing microglia from the adult mouse brain using a magnetic-activated cell sorting system. [PDF]

STAR Protoc
Park J, Barman B, Kim HK, Guo F.
europepmc   +1 more source

Gamma Delta T Cells in Shrimp Allergy Express a Unique Cytotoxic Cytokine Profile

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Shellfish allergy is the most common food allergy in adults and the third most common in children. γδ T cells have been identified as playing a critical role in antigen tolerance in allergic diseases in mouse models. In humans, γδ T cells may play a regulatory role in peanut immunotherapy, and their role in shrimp allergy remains unclear.
Brenda Bin Su, Tyler Jackson, Warren Blackmon, Harold Ames, Christopher Holt, Aikaterini Anagnostou, Vibha Szafron, Sara Anvari, Hongjie Li, Carla M. Davis   +9 more
wiley   +1 more source

Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell‐Activating Properties in B Cell Lymphoma

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
B cell lymphoma‐derived EVs are intrinsically neutral or suppressive with respect to NK cell activity (panel 1). In the context of rituximab treatment, NK cytotoxicity is enhanced by antibody‐dependent cell‐mediated cytotoxicity (panel 2). Herein we show that, in addition, rituximab recognition of EV‐associated CD20 generates immune complexes that ...
Adrián V. Otero, Paula Soledad Pérez, Belen Gaete‐Ramírez, Gregorio Cordini, Matías Norte, Enriqueta Martínez, Nicolás Marsol, Cecilia Malusardi, Sofía Rivarola, Ana Cantillo, María Luz Leicaj, Constanza Russo, Juan Quarroz Braghini, Federico Penas, Glenda Ernst, Cecilia Cabral, Silvina Palmer, Manuel Varas‐Godoy, Lourdes Arruvito, Matías Ostrowski   +19 more
wiley   +1 more source

Polymorphonuclear leukocytes (PMNs) use different, strain-dependent mechanisms to kill the parasite <i>Trichomonas vaginalis</i>. [PDF]

mBio
Mercer F, Mukherjee SK, Ho C-L, Muratore K, Johnson PJ.   +4 more
europepmc   +1 more source

HCV‐Specific T‐Cell Recovery After a Year of SVR Following DAA Therapy

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Direct‐acting antiviral (DAA) drugs lead to sustained virologic response (SVR) in almost all treated patients with chronic hepatitis C virus (HCV) infection. Despite this success, the long‐term effects of HCV clearance by DAA therapy on T‐cell‐mediated antiviral immunity remain unclear, particularly concerning the restoration of immune ...
Tetiana Pozniak, Salma Sharaf, Chloe Gross, Emade Ebah, Arshi Khanam, Amelia Cover, Ashley Davis, Shyam Kottilil, Poonam Mathur, Alip Ghosh   +9 more
wiley   +1 more source

CGRP restrains CD4⁺ T cell responses and allergic sensitization. [PDF]

Front Immunol
Li X, Zhang Y, Chen W, Meng Q, Huang A, Pan J, Chen D, Xiao Y, Wei J, Sun H, Liu Q.   +10 more
europepmc   +1 more source

Secure Decentralized Key Relaying via Random Walks in Dynamic Semi‐Trusted QKD Networks

Advanced Quantum Technologies, Volume 9, Issue 8, August 2026.
Quantum Key Distribution (QKD) provides point‐to‐point, information‐theoretically secure session keys, but distance limitations require trusted relays between remote parties. Can quantum keys be relayed without trusting every intermediate node or depending on a central controller?
Sergejs Kozlovičs, Krišjānis Petručeņa, Elina Kalnina, Juris Viksna   +3 more
wiley   +1 more source

The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis. [PDF]

PLoS Biol
Bellassen L, David K, Lampert B, Sarusi-Portuguez A, Tsoory M, Lubliner J, Hornstein E, Osherov M, Milo R, Brenner O, Becker-Herman S, Shachar I.   +11 more
europepmc   +1 more source

Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity

Small, Volume 22, Issue 45, 13 August 2026.
Lipid nanoparticle composition governs distinct cytokine programs through the interplay of ionizable and polyethylene glycol‐conjugated (PEGylated) lipids. In vitro profiling, design of experiments (DoE) modeling, and in vivo validation reveal how formulation can tune reactogenicity‐associated pathways, while transgene expression remains the strongest ...
Adam Alexander Walters, Belal I. Hanafy, Chuan‐En Lu, Sara Marelli, Alaa Zam, Kai Liu, Rachel E. Foreman, Ramesh Soundararajan, Philippe Collin, Lennart Lindfors, Alan Sabirsh, Mariarosa Mazza, Khuloud T. Al‐Jamal, Stephanie M. Bates, George Thom, Jan Rehwinkel, Alexander N Kapustin   +16 more
wiley   +1 more source