Results 181 to 190 of about 18,826 (294)
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu +12 more
wiley +1 more source
Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling. [PDF]
Liu H +12 more
europepmc +1 more source
Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao +12 more
wiley +1 more source
Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses. [PDF]
Baldino AM +5 more
europepmc +1 more source
Loss of KCNK16 in mice alters β‐cell insulin secretion dynamics leading to increased pancreatic insulin content and decreased circulating IGF‐1. Furthermore, body growth and adiposity were reduced independent of dietary interventions. Despite these changes, overall glucose tolerance and insulin sensitivity remain largely preserved.
Olena Früh +15 more
wiley +1 more source
From Zombies to Smart Devices: The Evolution of Dye-Sensitized Solar Cells for IoT Applications. [PDF]
Sasitharan K, Freitag M.
europepmc +1 more source
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen +7 more
wiley +1 more source
IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner. [PDF]
Yoshioka Y +19 more
europepmc +1 more source
Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition‐dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and ...
Sabine Daemen +5 more
wiley +1 more source

