Results 181 to 190 of about 18,826 (294)

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

open access: yesAdvanced Science, Volume 13, Issue 31, 4 June 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu   +12 more
wiley   +1 more source

Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling. [PDF]

open access: yesAdv Sci (Weinh)
Liu H   +12 more
europepmc   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 31, 4 June 2026.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao   +12 more
wiley   +1 more source

KCNK16 Deficiency Deteriorates Body Growth and Diet‐Independently Decreases Lipid Accumulation in Mice

open access: yesComprehensive Physiology, Volume 16, Issue 3, June 2026.
Loss of KCNK16 in mice alters β‐cell insulin secretion dynamics leading to increased pancreatic insulin content and decreased circulating IGF‐1. Furthermore, body growth and adiposity were reduced independent of dietary interventions. Despite these changes, overall glucose tolerance and insulin sensitivity remain largely preserved.
Olena Früh   +15 more
wiley   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen   +7 more
wiley   +1 more source

IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner. [PDF]

open access: yesNPJ Vaccines
Yoshioka Y   +19 more
europepmc   +1 more source

Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver

open access: yesEuropean Journal of Immunology, Volume 56, Issue 6, June 2026.
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition‐dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and ...
Sabine Daemen   +5 more
wiley   +1 more source

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