Results 91 to 100 of about 296 (198)
Innovation and zombie firms: Empirical evidence from Italy
Zombie firms are businesses that cannot repay debt from current profits over an extended period and yet continue to operate and avoid failure. This article specifically investigates whether and under what circumstances the presence of zombies in an industry constitutes a barrier to the innovativeness of non-zombies in the same sector. Conceptually, non-
Andrea Ascani, Lakshmi Balachandran Nair
openaire +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan +10 more
wiley +1 more source
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi +23 more
wiley +1 more source
The share of zombie firms in Germany
In recent years of economic slowdown and low policy rates, economies are in danger of accumulating unhealthy and unproductive firms. These zombie firms are unable to repay debt nor cover their interest obligations, kept alive by a continuous loan supply by unsound banks.
openaire +1 more source
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham +8 more
wiley +1 more source
Gamma Delta T Cells in Shrimp Allergy Express a Unique Cytotoxic Cytokine Profile
ABSTRACT Shellfish allergy is the most common food allergy in adults and the third most common in children. γδ T cells have been identified as playing a critical role in antigen tolerance in allergic diseases in mouse models. In humans, γδ T cells may play a regulatory role in peanut immunotherapy, and their role in shrimp allergy remains unclear.
Brenda Bin Su +9 more
wiley +1 more source
Competition and firm recovery post-COVID-19. [PDF]
Bruhn M, Demirguc-Kunt A, Singer D.
europepmc +1 more source
Lipid nanoparticle composition governs distinct cytokine programs through the interplay of ionizable and polyethylene glycol‐conjugated (PEGylated) lipids. In vitro profiling, design of experiments (DoE) modeling, and in vivo validation reveal how formulation can tune reactogenicity‐associated pathways, while transgene expression remains the strongest ...
Adam Alexander Walters +16 more
wiley +1 more source
COVID-19 and lending responses of European banks. [PDF]
Özlem Dursun-de Neef H, Schandlbauer A.
europepmc +1 more source

