Results 181 to 190 of about 643,451 (226)

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Simulation of the Hydro-ecological Impacts of Climate Change on an Upland Peatland in the Massif Central. [PDF]

Wetlands (Wilmington)
Thompson JR, Duranel A, Keisser E, Durepaire P, Cubizolle H.   +4 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Seasonal effects of farmer-managed livestock grazing exclusions on bird communities in Burkina Faso. [PDF]

Ecol Appl
Quintas I, Marcacci G, Zongo AN, Korner P, Kuttnig A, Spaar R, Diakité B, Kaguembèga-Müller F, Jacot A.   +8 more
europepmc   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Exposure of wetlands important for nonbreeding waterbirds to sea-level rise in the Mediterranean. [PDF]

Conserv Biol
Verniest F, Galewski T, Boutron O, Dami L, Defos du Rau P, Guelmami A, Julliard R, Popoff N, Suet M, Willm L, Abdou W, Azafzaf H, Bendjedda N, Bino T, Borg JJ, Božič L, Dakki M, Hamoumi RE, Encarnação V, Erciyas-Yavuz K, Etayeb K, Georgiev V, Hamada A, Hatzofe O, Ieronymidou C, Langendoen T, Mikuska T, Molina B, Moniz F, Moussy C, Ouassou A, Petkov N, Portolou D, Qaneer T, Sayoud S, Šćiban M, Topić G, Uzunova D, Vine G, Vizi A, Xeka E, Zenatello M, Gaget E, Viol IL.   +43 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Adaptive evolution of stress response genes in parasites aligns with host niche diversity. [PDF]

BMC Biol
Cruz-Laufer AJ, Vanhove MPM, Bachmann L, Barson M, Bassirou H, Bitja Nyom AR, Geraerts M, Hahn C, Huyse T, Kasembele GK, Njom S, Resl P, Smeets K, Kmentová N.   +13 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source