Results 201 to 210 of about 29,910 (286)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

A parasite through time: Revisiting <i>Trypanosoma rajae</i> Laveran and Mesnil, 1902 with new molecular and morphological insights from the blood of Rajidae in the western Mediterranean. [PDF]

Int J Parasitol Parasites Wildl
Kefil S, Duval L, Labat A, Bouguerche C, Kechemir-Issad N.   +4 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Populations de glossines et occupation de l'espace : enquête entomologique préliminaire dans la région de la Lobo (Côte d'Ivoire), février 1981 [PDF]

, 1981
Hervouët, Jean-Pierre, Laveissière, Claude   +1 more
core  

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Exposure of wetlands important for nonbreeding waterbirds to sea-level rise in the Mediterranean. [PDF]

Conserv Biol
Verniest F, Galewski T, Boutron O, Dami L, Defos du Rau P, Guelmami A, Julliard R, Popoff N, Suet M, Willm L, Abdou W, Azafzaf H, Bendjedda N, Bino T, Borg JJ, Božič L, Dakki M, Hamoumi RE, Encarnação V, Erciyas-Yavuz K, Etayeb K, Georgiev V, Hamada A, Hatzofe O, Ieronymidou C, Langendoen T, Mikuska T, Molina B, Moniz F, Moussy C, Ouassou A, Petkov N, Portolou D, Qaneer T, Sayoud S, Šćiban M, Topić G, Uzunova D, Vine G, Vizi A, Xeka E, Zenatello M, Gaget E, Viol IL.   +43 more
europepmc   +1 more source

CONSULTATIVE COMMITTEE FOR THE HUMID TROPICAL ZONE / COMITÉ CONSULTATIF DE LA ZONE TROPICALE HUMIDE [PDF]

International Association of Scientific Hydrology. Bulletin, 1958
openaire   +1 more source

Contribution à l'étude des zones humides littorales de l'Ouest Africain : étude de cas : secteur géographique M'Bour-Djifère (Petite Côte-Sénégal) [PDF]

, 1986
Baillon, François, Greth, A.
core  

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source