Results 51 to 60 of about 5,464 (253)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Expanding the Zooarchaeology by Mass Spectrometry reference library for North American mammals: new collagen fingerprints from extinct and extant taxaExpanding the Zooarchaeology by Mass Spectrometry reference library for North American mammals: new collagen fingerprints from extinct and extant taxa [PDF]

Royal Society Open Science
Robust zooarchaeological analysis of Pleistocene-Holocene faunal assemblages is fundamental for reconstructing past environments, species distributions, human subsistence and faunal turnovers in North America.
Mariya Antonosyan, Carli Peters, Eden Hill, Bryan Hockett, Robert S. Feranec, Madeline E. Mackie, Matthew Gibson, Dennis Jenkins, Torben C. Rick, Noel Amano, Patrick Roberts, Nicole Boivin   +11 more
doaj   +1 more source

MALDI-TOF-MS reference spectra and sequence data for domesticated equids (horse and donkey) collagen for Zooarchaeology by Mass Spectrometry (ZooMS)

, 2022
MALDI-TOF-MS spectra of extracted collagen from modern reference and archaeological bone samples to develop markers for Zooarchaeology by Mass Spectrometry (ZooMS) to distinguish between Equus species.
Richter, Kristine Korzow, Gabriel, Sonia, Barrocas Dias, Cristina, Warinner, Christina, Valente, Maria João, Paladugu, Roshan, Detry, Cleia   +6 more
core   +1 more source

The effect of eraser sampling for proteomic analysis on Palaeolithic bone surface microtopography

Scientific Reports, 2021
Bone surface modifications are crucial for understanding human subsistence and dietary behaviour, and can inform about the techniques employed in the production and use of bone tools. Permission to destructively sample such unique artefacts is not always
Virginie Sinet-Mathiot, Naomi L. Martisius, Ellen Schulz-Kornas, Adam van Casteren, Tsenka R. Tsanova, Nikolay Sirakov, Rosen Spasov, Frido Welker, Geoff M. Smith, Jean-Jacques Hublin   +9 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Collagen peptide markers for three extinct Australian megafauna species

Frontiers in Mammal Science
Recent advancements in biomolecular archaeology, such as stable isotope and ancient DNA research, have expanded our understanding of megafauna extinction processes and dynamics.
Carli Peters, Carli Peters, Annette Oertle, Annette Oertle, Richard Gillespie, Nicole Boivin, Nicole Boivin, Nicole Boivin, Katerina Douka, Katerina Douka   +9 more
doaj   +1 more source

Editorial for Localising the Sustainable Human Right to Water

Utrecht Law Review, 2020
This Special Issue on Localising the Sustainable Human Right to Water begins with contributions focused on a global and more general perspective. These contributions provide a general introduction to the topic of the sustainable human right to water.
Otto Spijkers, Daphina Misiedjan, Candice Foot, Marleen van Rijswick   +3 more
doaj   +1 more source

A double-blind comparison of morphological and collagen fingerprinting (ZooMS) methods of skeletal identifications from Paleolithic contexts

Scientific Reports, 2023
Modeling the subsistence strategies of prehistoric groups depends on the accuracy of the faunal identifications that provide the basis for these models.
Eugène Morin, Ellie-May Oldfield, Mile Baković, Jean-Guillaume Bordes, Jean-Christophe Castel, Isabelle Crevecoeur, Hélène Rougier, Gilliane Monnier, Gilbert Tostevin, Michael Buckley   +9 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source