Results 11 to 20 of about 24,369 (234)

SARS‐CoV‐2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

open access: yesJournal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The coronavirus disease 2019 (COVID‐19) continues to pose a major threat to public health worldwide. Although many studies have clarified the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection process, the underlying mechanisms of viral invasion and immune evasion were still unclear.
Shun Li   +8 more
wiley   +1 more source

T Cell Activating Thermostable Self‐Assembly Nanoscaffold Tailored for Cellular Immunity Antigen Delivery

open access: yesAdvanced Science, Volume 10, Issue 26, September 15, 2023., 2023
The study redirects antigenic properties of the thermostable self‐assembly nanoscaffold Aquifex aeolicus lumazine synthase (AaLS) for T‐cell immunity‐dependent antigen delivery. Compared to AaLS, the ab initio designed nanoscaffold‐constructed nanovaccines elicit more potent cytotoxic T cell and CD4+ T helper 1‐biased immune responses, and generate ...
Jinsong Zhang   +11 more
wiley   +1 more source

Azvudine therapy of common COVID‐19 in hemodialysis patients

open access: yesJournal of Medical Virology, Volume 95, Issue 8, August 2023., 2023
Abstract There is no antiviral study on hemodialysis patients infected with coronavirus disease 2019 (COVID‐19), especially on the application of 2′‐deoxy‐2′‐β ‐fluoro‐4′‐azidocytidine (Azvudine, FNC) antiviral therapy. We conducted a multicenter observational study involving 1008 hemodialysis patients.
Shunlai Shang   +11 more
wiley   +1 more source

NLRC4 promotes the cGAS‐STING signaling pathway by facilitating CBL‐mediated K63‐linked polyubiquitination of TBK1

open access: yesJournal of Medical Virology, Volume 95, Issue 8, August 2023., 2023
Abstract TANK‐binding kinase 1 (TBK1) is crucial in producing type Ⅰ interferons (IFN‐Ⅰ) that play critical functions in antiviral innate immunity. The tight regulation of TBK1, especially its activation, is very important. Here we identify NLRC4 as a positive regulator of TBK1.
Rongzhao Zhang   +5 more
wiley   +1 more source

La régulation des marchés aux animaux (wetmarkets) en Chine durant la crise de Covid-19

open access: yesMétropoles, 2023
While the health crises of the last twenty years have highlighted China's wet markets as potential transmission sites for zoonotic pathogens such as influenza viruses or SARS coronaviruses, Chinese consumers have maintained a demand for freshness and ...
Frédéric Keck, Nan Nan
doaj   +1 more source

Leishmaniose visceral humana: reflexões éticas e jurídicas acerca do controle do reservatório canino no Brasil

open access: yesRevista de Bioética y Derecho, 2017
O Brasil enfrenta atualmente dificuldades no combatea leishmaniose visceral humana.De acordo a Organização Mundial da Saúde, a eutanásia dos cães sintomáticos e soropositivos é uma das medidas de controle do agravo, conforme decreto vigente 51.838, de 14
Savio Pereira da Silva   +4 more
doaj   +1 more source

Chlamydial Zoonoses [PDF]

open access: yesDeutsches Ärzteblatt international, 2010
Zoonoses were already a subject of intense interest even before the SARS and avian influenza epidemics arose. For many years, chlamydiae have been hypothesized to be important zoonotic pathogens, because of their wide distribution and their infectious cycle. This article provides an overview of the current state of knowledge on this subject.The authors
Gernot, Rohde   +4 more
openaire   +2 more sources

Ciliate research: From myth to trendsetting science

open access: yesJournal of Eukaryotic Microbiology, Volume 69, Issue 5, September/October 2022., 2022
Abstract This special issue of the Journal of Eukaryotic Microbiology (JEM) summarizes achievements obtained by generations of researchers with ciliates in widely different disciplines. In fact, ciliates range among the first cells seen under the microscope centuries ago.
Helmut Plattner
wiley   +1 more source

The Redox-Sensing Regulator Rex Contributes to the Virulence and Oxidative Stress Response of Streptococcus suis Serotype 2

open access: yesFrontiers in Cellular and Infection Microbiology, 2018
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen responsible for septicemia and meningitis. The redox-sensing regulator Rex has been reported to play critical roles in the metabolism regulation, oxidative stress response, and ...
Haodan Zhu   +21 more
doaj   +1 more source

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