Results 61 to 70 of about 97,130 (332)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

open access: yesAdvanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang   +13 more
wiley   +1 more source

Zoonotic diseases associated with pet birds

open access: yesJournal of Zoonotic Diseases, 2022
Birds are the most popular pet animals kept by humans in many areas of the world. Budgerigars, Canaries, Lovebirds, and Cockatiels are the most common pet birds. Zoonotic diseases are one of the most critical concerns related to pet birds worldwide.
Seyedeh Alemeh Hosseinian
doaj   +1 more source

Genome Sequences of Three Lactobacillus Species Strains of the Stomach of the White-Footed Deermouse (Peromyscus leucopus). [PDF]

open access: yes, 2019
Three colony types of Lactobacillus were isolated from the stomach of LL colony stock Peromyscus leucopus deermice, a reservoir for several human zoonoses.
Barbour, Alan G   +2 more
core  

Nasal Bacterial Microbiome: Probing a Healthy Porcine Family [PDF]

open access: yes, 2011
Upper respiratory tract (URT) infection caused the leading and devastating diseases in pigs. It was believed that the normal microbiome of URT plays a vital role in health and disease development.
Huanchun Chen, Min Yue, Weicheng Bei
core   +2 more sources

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

open access: yesAdvanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang   +22 more
wiley   +1 more source

Zoonoses

open access: yes, 2009
Zoonoses are the ‘diseases and infections that are naturally transmitted between vertebrate animals and man,’ as defined in 1951 by the World Health Organization (WHO) Expert Committee on Zoonoses. The word zoonosis (plural zoonoses) is the combination of two Greek words (zoon, animals and noson, disease), and was coined at the end of the nineteenth ...
openaire   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

open access: yesAdvanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li   +9 more
wiley   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

open access: yesAdvanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi   +8 more
wiley   +1 more source

Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru [PDF]

open access: yes, 2018
Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have ...
A. Appelgren   +9 more
core   +3 more sources

Relationship Between Knowledge and Compliance With Safety Measures: Evidence From COVID‐19

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Compliance with health safety protocols is important for protecting public health, particularly in agricultural sectors where disease outbreaks can disrupt production and market access. Despite its economic significance, we know little about what drives protocol compliance.
Nilufer Cetik   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy