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The Immunology of Zoonotic Infection [PDF]

Tropical Medicine and Infectious Disease, 2022
Zoonotic infection can threaten public health locally and globally [...]
Yang Li, Qiuchun Li
doaj   +5 more sources

Urban rat exposure to anticoagulant rodenticides and zoonotic infection risk [PDF]

Biology Letters, 2021
Cecilia A Sánchez, Maureen H Murray
exaly   +2 more sources

Immune-Mediated Mechanisms of COVID-19 Neuropathology

Frontiers in Neurology, 2022
Although SARS-CoV-2 causes a respiratory viral infection, there is a large incidence of neurological complications occurring in COVID-19 patients. These range from headaches and loss of smell to encephalitis and strokes.
Cordelia Dunai, Cordelia Dunai, Ceryce Collie, Benedict D. Michael, Benedict D. Michael, Benedict D. Michael   +5 more
doaj   +1 more source

Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2

Biomedicines, 2022
The natural plant dietary polyphenols 1,2,3,4,6-O-Pentagalloylglucose (PGG) and proanthocyanidin (PAC) have potent antioxidant activity and a variety of pharmacological activities, including antiviral activity.
Young-Hee Jin, Jihye Lee, Sangeun Jeon, Seungtaek Kim, Jung Sun Min, Sunoh Kwon   +5 more
doaj   +1 more source

Estimating the potential for global dissemination of pandemic pathogens using the global airline network and healthcare development indices

Scientific Reports, 2022
Pandemics have the potential to incur significant health and economic impacts, and can reach a large number of countries from their origin within weeks. Early identification and containment of a newly emerged pandemic within the source country is key for
Margaux M. I. Meslé, Roberto Vivancos, Ian M. Hall, Robert M. Christley, Steve Leach, Jonathan M. Read   +5 more
doaj   +1 more source

Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections

Pharmaceutics, 2021
Cardiotonic steroids are steroid-like natural compounds known to inhibit Na+/K+-ATPase pumps. To develop a broad-spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds.
Young-Hee Jin, Sangeun Jeon, Jihye Lee, Seungtaek Kim, Min Seong Jang, Chul Min Park, Jong Hwan Song, Hyoung Rae Kim, Sunoh Kwon   +8 more
doaj   +1 more source

SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study

Viruses, 2021
The recent SARS-CoV-2 pandemic has brought many questions over the origin of the virus, the threat it poses to animals both in the wild and captivity, and the risks of a permanent viral reservoir developing in animals.
Tessa Prince, Shirley L. Smith, Alan D. Radford, Tom Solomon, Grant L. Hughes, Edward I. Patterson   +5 more
doaj   +1 more source

Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care

Genome Medicine, 2021
Background Ebola virus disease (EVD) is an often-fatal infection where the effectiveness of medical countermeasures is uncertain. During the West African outbreak (2013–2016), several patients were treated with different types of anti-viral therapies ...
Andrew Bosworth, Natasha Y. Rickett, Xiaofeng Dong, Lisa F. P. Ng, Isabel García-Dorival, David A. Matthews, Tom Fletcher, Michael Jacobs, Emma C. Thomson, Miles W. Carroll, Julian A. Hiscox   +10 more
doaj   +1 more source

Anticoronaviral Activity of the Natural Phloroglucinols, Dryocrassin ABBA and Filixic Acid ABA from the Rhizome of Dryopteris crassirhizoma by Targeting the Main Protease of SARS-CoV-2

Pharmaceutics, 2022
The rhizome of Dryopteris crassirhizoma Nakai. (Dryopteridaceae) has been used in traditional medicine in East Asia and has recently been reported to have anticancer, anti-inflammation, and antibacterial activity as well as antiviral activity.
Young-Hee Jin, Sangeun Jeon, Jihye Lee, Seungtaek Kim, Min Seong Jang, Chul Min Park, Jong Hwan Song, Hyoung Rae Kim, Sunoh Kwon   +8 more
doaj   +1 more source

COVID-19 as a zoonotic infection

Инфекция и иммунитет, 2021
Here we discuss the issues for attributing the new coronavirus infection COVID-19 to zoonoses based on the data on probable origin of the SARS-CoV-2 virus, the possible formation of its reservoir in animals (bats) as well as human susceptibility.
A. N. Kulichenko, O. V. Maletskaya, N. S. Sarkisyan, A. S. Volynkina   +3 more
doaj   +1 more source