Results 61 to 70 of about 309 (104)

Recovery from Zoxazolamine Paralysis and Metabolism in vitro of Zoxazolamine in Ageing Mice

Nature, 1971
SENESCENCE has been viewed as the progressive loss or diminution of the ability of an organism to regulate or maintain obligatory levels of activity of its various enzymes1–8. The primary reason(s) for this age-dependent loss in regulatory capacity is unknown.
Baird, M, Samis, H, Massie, H
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ZOXAZOLAMINE AND/OR CHLORPROMAZINE FOR MUSCLE SPASM

Journal of the American Medical Association, 1957
Eight patients who had skeletal muscle spasticities due to spinal cord injuries received various combinations of four drugs, (1) zoxazolamine, (2) a placebo resembling zoxazolamine, (3) chlorpromazine, and (4) a placebo resembling chlorpromazine. Each patient's status with respect to muscular spasticities was evaluated objectively by observers who ...
J W, GIBSON, S S, BLUESTONE, E W, LOWMAN
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Prolongation of Chlorzoxazone Plasma Levels by Zoxazolamine

Journal of Pharmaceutical Sciences, 1963
The plasma levels of chlorzoxazone were determined in humans, dogs, and mice. It was shown that the co-administration of zoxazolamine and chlorzoxazone prolonged the plasma concentrations of the latter substance in mice and dogs. An interaction between the compounds under consideration, which resulted in the formation of an insoluble complex, was ...
J W, POOLE, J F, GARDOCKI
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Pharmacodynamics of Zoxazolamine and Chlorzoxazone in Rats

Pharmaceutical Research, 1988
Zoxazolamine is used for the pharmacologic assessment of possible changes in oxidative enzyme activity (paralysis time test) in rodents, whereas one of its metabolites, chlorzoxazone, is used clinically as a skeletal muscle relaxant. In this investigation, the pharmacodynamics of the two compounds were characterized in normal adult rats to determine ...
M, Yasuhara, G, Levy
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Nephrotoxicity Associated with Zoxazolamine Administration

New England Journal of Medicine, 1959
ZOXAZOLAMINE† has been in use since 1956 as a relaxant of skeletal-muscle spasm. Amols1 found the drug to be useful, safe and productive of few side effects.
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Dose-dependent pharmacokinetics of zoxazolamine in the rat.

Drug Metabolism and Disposition, 1986
Zoxazolamine (ZX) is a model substrate frequently used in studies on (methylcholanthrene-inducible) hepatic cytochrome P-450 activity. The iv pharmacokinetics of ZX were studied in rats at four dose levels: 5 mg X kg-1 (n = 6), 25 mg X kg-1 (n = 6), 50 mg X kg-1 (n = 5), and 60 mg X kg-1 (n = 4).
Van der Graaff, M, Vermeulen, N P, Crul, I E, Breimer, D D   +3 more
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In Vivo Activation of Zoxazolamine Metabolism by Flavone

Science, 1982
The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate severalfold stimulation in the rate of total body ...
J M, Lasker, , Huang M-T, A H, Conney
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EFFECT OF ZOXAZOLAMINE (FLEXIN) IN TREATMENT OF SPASTICITY

Journal of the American Medical Association, 1956
• Zoxazolamine was administered to patients with spasticity and other forms of uncontrolled muscular activity ascribed to disease in either the spinal cord or the brain. The expected relaxing effect was best seen in patients with lesions in the spinal cord, especially multiple sclerosis. Of 18 patients in the spinal group, 14 showed undoubted reduction
M, RODRIGUEZ-GOMEZ, A, VALDES-RODRIGUEZ, A L, DREW   +2 more
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Contrasting effects of thyroxin on zoxazolamine and hexobarbital metabolism

Biochemical Pharmacology, 1961
Abstract Administration of thyroxin to rats: (a) shortens the duration of action of zoxazolamine (2-amino-5-chlorobenzoxazole by accelerating its metabolism, and (b) prolongs the duration of action of hexobarbital by inhibiting its metabolism. Administration of the hormone does not alter the activity of the zoxazolamine-metabolizing enzyme system in ...
A H, CONNEY, L, GARREN
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USE OF ZOXAZOLAMINE (FLEXIN) IN CHILDREN WITH CEREBRAL PALSY

Journal of the American Medical Association, 1956
• In one set of observations on 10 children with severe mental retardation, increased tendon reflexes, and resistance to passive motion, the dosage of zoxazolamine needed to produce a definite decrease in muscle tone was found to range from 30 to 140 mg. per kilogram per day. This dosage caused side-effects in eight, with vomiting in three. Respiratory
E H, ABRAHAMSEN, H W, BAIRD
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