Results 231 to 240 of about 132,707 (291)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Immune checkpoint blockade as an accelerator of adrenal aging: a testable model linking low-grade cortical inflammation to proteostasis failure, LDLR/SULT2A1 suppression, and reduced DHEA output. [PDF]

J Immunother Cancer
Ding G, Xu Y, Guo T, Feng C.
europepmc   +1 more source

Entropy Decoding the Fundamental Law of Phase Competition in Glass Formation

Advanced Science, EarlyView.
We validate the integration of intermetallic and eutectic phases as initial phases for composition design. The phase competition mechanism in glass formation is quantitatively clarified based on the melting entropy of competing phases. Glass‐forming ability is modulated by tuning phase competition via the melting entropy of initial phases.
Benke Huo, Zhengqing Cai, Bingtao Wang, Zhenqiang Song, Shi‐Dong Feng, Zijing Li, Xingjun Liu, Li‐Min Wang   +7 more
wiley   +1 more source

Dominant clones leverage developmental epigenomic states to drive ependymoma. [PDF]

Nature
Kardian AS, Sun H, Ippagunta S, Laboe N, Varadharajan S, Yu K, Chen HC, Emanus E, Zheng T, Deneen RM, Connelly JP, Wang YD, Zhan J, Liu H, Lowe K, Bugbee T, Pathak R, Bland A, Mehta S, Cochiolo S, Arabzade A, Holcomb B, Budd KM, Kembuan G, Wright T, Caesar E, Park M, Hancock A, Gee D, Murdoch J, Xiao Y, McBrayer SK, Merchant TE, Qi J, Durbin AD, Schwarz LA, Wang L, Donson AM, Foreman NK, Agnihotri S, Lavado A, Baker SJ, Ellison DW, Lee HK, Pruett-Miller SM, Bertrand KC, Deneen B, Mack SC.   +47 more
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Zircon behavior in the partially melted planetary mantle

Yakimenko A, Borisova A, Fedortchouk Y, Fairhurst L.   +3 more
europepmc   +1 more source

Integrated radio-theranostics using a [⁸⁹Zr]Zr-/[¹⁷⁷Lu]Lu-labeled B7-H3 antibody-drug conjugate for prostate cancer. [PDF]

Theranostics
Qiu Y, Gu T, Wang T, Mulati Y, Sun X, Yang Q, Song L, Yuan T, Fan Y, Kang L, Cai W.   +10 more
europepmc   +1 more source

Colossal Photovoltaic Current in Ferroelectric Oxide by Constructing Defect Band

Advanced Science, EarlyView.
Colossal photovoltaic current density of 34.36 mA/cm2 under 375 nm illumination has been achieved in the Pb‐deficient PbTiO3 film. The ultraviolet photoresponsivity surpasses that of all reported ferroelectric materials. This enhancement is attributed to the junction effect between the Pb‐deficient and non‐defective layers.
Yiran Sun, Zhenbang Dai, Xingzhong Cao, Peng Zhang, Chen Lin, Zihang Huang, Ruian Zhang, Yi Fu, Xuanyu Jiang, He Tian, Jingjing Xue, Kaifeng Wu, Junhui Wang, Tianqi Deng, Andrew M. Rappe, Gaorong Han, Zhaohui Ren   +16 more
wiley   +1 more source

Glycoprotein mucin 13 expression as a theranostic target in colorectal cancer. [PDF]

Clin Cancer Res
Yamaguchi A, Coll RP, Wang J, Bae SW, Tran H, Huang B, Mashimo T, Schuler FW, Lin SJ, Sharma S, Dhakshinamoorthy S, Ta RT, Georgiou DK, Karacosta LG, Malik S, Khan S, Yallapu MM, Kopetz S, Chauhan SC, Manning HC.   +19 more
europepmc   +1 more source