Results 81 to 90 of about 32,279 (227)

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF‐κB‐SREBP1 Pathway Inhibition

Aging Cell, Volume 24, Issue 12, December 2025.
Human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs) ameliorate age‐related cognitive decline by targeting senescent microglia. They attenuate microglial senescence, reduce LD accumulation, and inhibit the NF‐κB‐SREBP1 signaling pathway, ultimately mitigating neuroinflammation and neuronal damage.
Aihong Liang, Li Zhang, Jing Peng, Yanan Li, Yunduo Zhou, Chao Yang, Jie Wang, Yizhong Yan, Hua Mei, Jun Zhu, Siqi Wang, Na Xiao, Yu Zhou, Lamei Cheng   +13 more
wiley   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +2 more sources

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, Volume 45, Issue 11, Page 1547-1578, November 2025.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks

Scientific Reports
Cells of the innate immune system retain memory of prior exposures through a process known as innate immune training. β-glucan, a Dectin-1 ligand purified from the Candida albicans cell wall, has been one of the most widely utilized ligands for inducing ...
Quen J. Cheng, Kylie Farrell, Jeffrey Fenn, Zuchao Ma, Sara K. Makanani, Jonathan Siemsen   +5 more
doaj   +1 more source

The Phenotypical and Functional Effect of PGE2 on Human Macrophages

European Journal of Immunology, Volume 55, Issue 11, November 2025.
Prostaglandin E2 (PGE2) signaling through E‐prostanoid receptors (EP) 2 and 4 induces a distinct human macrophage phenotype and affects their functions. Targeting the PGE2‐EP2/4 axis in macrophages with soluble or nanoparticle‐encapsulated EP2/4 antagonists counteracts the PGE2‐induced effect in a 2D and 3D tumor microenvironment using patient‐derived ...
Maren Pfirrmann, Johanna Bödder, Rowan Wuestenenk, Jesse Tennebroek, Kirti K. lyer, Dennis Poel, Daniele V.F. Tauriello, Martijn Verdoes, I. Jolanda M. de Vries   +8 more
wiley   +1 more source