Results 11 to 20 of about 107,140 (318)
Antiviral Research, 2020 Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
Touret, Franck, de Lamballerie, Xavier
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Cell Research, 2020 Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.
Manli Wang +9 more
semanticscholar +1 more source
Nature Communications, 2021 Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine
C. Axfors +93 more
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BioScience Trends, 2020 The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China.
Jianjun Gao, Zhenxue Tian, Xu Yang
semanticscholar +1 more source
Cell Discovery, 2020 Dear Editor, The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local economies.
Jia Liu +9 more
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JAMA Network Open, 2020 Key Points Question How safe and effective are 2 different regimens of chloroquine diphosphate in the treatment of severe coronavirus disease 2019 (COVID-19)? Findings In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned
semanticscholar +1 more source
The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2020 Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid ...
M.Dedi Dermawan Dermawan +3 more
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Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies
BMC Bioinformatics, 2019 Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu +3 more
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Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti
Emerging Infectious Diseases, 2012 Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger +3 more
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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 2018 Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation.
Mario Mauthe +9 more
semanticscholar +1 more source