Results 11 to 20 of about 391,284 (388)

Evolution of the germline mutation rate across vertebrates

Nature, 2023
The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself^ 1 . However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different ...
Bergeron La, Besenbacher S, Zheng J, Li P, Bertelsen Mf, Quintard B, Hoffman Ji, L. Z, S. J, Shao C, S. J, Gilbert Mtp, Schierup Mh, Zhang G   +13 more
semanticscholar   +1 more source

Feeding the germline [PDF]

Genes & Development, 2016
Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307–320) have usedCaernohabditis elegansto identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
Cheng Shi, Coleen T. Murphy
openaire   +3 more sources

Epigenetics and the germline [PDF]

Reproduction, 2005
Epigenetic processes affect three stages of germline development, namely (1) specification and formation of primordial germ cells and their germline derivatives through lineage-specific epigenetic modifications, in the same manner as other embryonic lineages are formed, (2) a largely genome-wide erasure and re-establishment of germline-specific ...
Lorraine E. Young, Alexandra Thurston, Emma S. Lucas, Cinzia Allegrucci   +3 more
openaire   +3 more sources

Germline chromatin [PDF]

WormBook, 2006
The DNA in eukaryotes is wrapped around a histone octamer core, together comprising the main subunit of chromatin, the nucleosome. Modifications of the nucleosomal histones in the genome correlate with the ability or inability of chromatin to form higher order structures, that in turn influence gene activity.
Christine E, Schaner, William G, Kelly
openaire   +2 more sources

On the origin of the human germline [PDF]

Development, 2018
ABSTRACT In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study because of the technical and ethical constraints that limit direct studies on human embryos. In recent
Toshihiro Kobayashi, Toshihiro Kobayashi, M. Azim Surani, M. Azim Surani   +3 more
openaire   +2 more sources

Characterization of germline development and identification of genes associated with germline specification in pineapple [PDF]

Horticulture Research, 2021
Abstract Understanding germline specification in plants could be advantageous for agricultural applications. In recent decades, substantial efforts have been made to understand germline specification in several plant species, including Arabidopsis, rice, and maize.
Xingyue Jin, Xiaomei Wang, Zhimin Hou, Lulu Wang, Liping Liu, Yanhui Liu, Adrien Sicard, Mohammad Aslam, Mohammad Aslam, Hanyang Cai, Yuan Qin, Yuan Qin, Lihua Zhao, Lihua Zhao, Xianying Dou, Yi Li, Heming Zhao   +16 more
openaire   +4 more sources

Can Unicellular Organisms Sequester a Germline? The Yeast-Germline Hypothesis. [PDF]

Bioessays
ABSTRACTGermline mutations can affect future generations, while somatic mutations cannot. This germline‐soma distinction does not seem to make sense for unicellular organisms. We challenge this view, arguing that baker's yeast (Saccharomyces cerevisiae) has a germline.
Vadlamudi BS, Aanen DK.
europepmc   +3 more sources

Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines

JAMA Network Open, 2022
Key Points Question What is the prevalence of germline findings in cancers lacking hereditary testing guidelines? Findings In this cross-sectional study including records from 34 642 patients, approximately 7% of patients with cancer harbored pathogenic ...
T. Yap, Arya Ashok, J. Stoll, E. Mauer, Vanessa M. Nepomuceno, K. Blackwell, J. Garber, F. Meric-Bernstam   +7 more
semanticscholar   +1 more source

Protecting and Diversifying the Germline [PDF]

Genetics, 2018
Abstract Gametogenesis represents the most dramatic cellular differentiation pathways in both female and male flies. At the genome level, meiosis ensures that diploid germ cells become haploid gametes. At the epigenome level, extensive changes are required to turn on and shut off gene expression in a precise spatiotemporally controlled ...
Xin Chen, Ryan J. Gleason, Toshie Kai, Amit Anand   +3 more
openaire   +2 more sources

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? [PDF]

Biology Open, 2021
ABSTRACTIn vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of shortcomings may be that model organisms used to characterize basic vertebrate embryology ...
Aaron M. Savage, Ramiro Alberio, Andrew D. Johnson   +2 more
openaire   +5 more sources