Results 11 to 20 of about 568,627 (261)

Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation

Journal of Nanobiotechnology, 2023
Inhibition of tumor growth and normalization of immune responses in the tumor microenvironment (TME) are critical issues for improving cancer therapy. However, in the treatment of glioma, effective nanomedicine has limited access to the brain because of ...
Ji-Seong Kim, Ying Zhu, Sunhui Chen, Dongdong Wang, Shuya Zhang, Jiaxuan Xia, Shiyi Li, Qiujun Qiu, Hyukjin Lee, Jianxin Wang   +9 more
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Diffuse Glioma Heterogeneity and Its Therapeutic Implications.

Cancer Discovery, 2021
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies.
James G Nicholson, H. Fine
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Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Frontiers in Oncology, 2020
Methylation of DNA, RNA or protein is a reversible modification. The proteins and genes that regulate this modification can be a candidate target for tumor therapy. However, the characteristics of methyltransferase related genes in glioma remain obscure.
Ying Zhang, Ying Zhang, Yuqing Liu, Yuqing Liu, Hanjie Liu, Hanjie Liu, Zheng Zhao, Zheng Zhao, Fan Wu, Fan Wu, Fan Zeng, Fan Zeng   +11 more
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Immunological profiles of human oligodendrogliomas define two distinct molecular subtypesResearch in context

EBioMedicine, 2023
Summary: Background: Human oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion.
Fan Wu, Yi-Yun Yin, Wen-Hua Fan, You Zhai, Ming-Chen Yu, Di Wang, Chang-Qing Pan, Zheng Zhao, Guan-Zhang Li, Wei Zhang   +9 more
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TERT mutations-associated alterations in clinical characteristics, immune environment and therapy response in glioblastomas

Discover Oncology, 2023
Objective TERT is the most frequently mutated gene in adult glioblastomas (GBMs) defined by the 2021 World Health Organization classification system. The present study aims to explore differences in clinical characteristics and immune microenvironment ...
Feng Tang, Xi Chen, Jin-Sheng Liu, Zhen-Yuan Liu, Jin-Zhou Yang, Ze-Fen Wang, Zhi-Qiang Li   +6 more
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EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Molecular Cancer, 2022
Background Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis.
Z. Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, W. Qiu, Q. Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, J. Qiu, Qingtong Wang, Xing Guo, Lin Deng, Ping Zhang, H. Xue, Gang Li   +21 more
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Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

Nature Communications, 2021
Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that ...
Natalia Ochocka, Pawel Segit, Kacper Adam Walentynowicz, K. Wojnicki, S. Cyranowski, Julian Swatler, J. Mieczkowski, B. Kamińska   +7 more
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Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression

Molecular Therapy: Nucleic Acids, 2022
High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang, Chao Yang, Feng-Ping Li, Dong-Hu Yu, Zhi-Yong Pan, Ze-Fen Wang, Zhi-Qiang Li   +6 more
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Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance.

Neuro-Oncology, 2022
BACKGROUND Immunosuppressive microenvironment is a major cause of immunotherapeutic resistance in glioma. In addition to secreting compounds, tumor cells under programmed cell death (PCD) processes release abundant mediators to modify the neighboring ...
Tianqi Liu, Chen Zhu, Xin Chen, Ge-fei Guan, Cunyi Zou, Shuai Shen, Jianqi Wu, Yuhang Wang, Zhiguo Lin, Ling Chen, Peng Cheng, Wen Cheng, A. Wu   +12 more
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Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing

Frontiers in Neurology, 2023
ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang, Chuan-bao Zhang, Zhi-liang Wang, Zhi-liang Wang, Han-jie Liu, Han-jie Liu, Zheng Wang, Zheng Wang, Wang Jia, Wang Jia   +9 more
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