Results 11 to 20 of about 22,728 (180)

Quantitative electroencephalographic analysis of delirium tremens development following alcohol‐withdrawal seizure based on a small number of male cases

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Considering the complications related to alcohol withdrawal syndrome (AWS) such as seizure, delirium tremens and cardiac arrhythmia, it is important to identify the risk of delirium tremens (DT) following AWS and enhance preventive strategies. We observed the characteristics of quantitative electroencephalography in patients with AWS, specifically who ...
Jee‐Eun Yoon, Heejung Mo, Dong Wook Kim, Hee‐Jin Im   +3 more
wiley   +1 more source

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Dermatological Reviews, Volume 3, Issue 5, Page 326-335, October 2022., 2022
Abstract Vitiligo is a chronic skin condition that results in depigmentation. It affects up to 2% of the population worldwide. Phototherapy is one of the most commonly used treatment methods for vitiligo. In the last few decades, there has been an increasing popularity of narrowband ultraviolet B phototherapy (NB‐UVB) over other forms of phototherapy ...
Eugene Wang, Michelle Rodrigues
wiley   +1 more source

A cross‐sectional clinical study in women to investigate possible genotoxicity and hematological abnormalities related to the use of black cohosh botanical dietary supplements

Environmental and Molecular Mutagenesis, Volume 63, Issue 8-9, Page 389-399, December 2022., 2022
Abstract Black cohosh (BC; Actaea racemosa L.), a top‐selling botanical dietary supplement, is marketed to women primarily to ameliorate a variety of gynecological symptoms. Due to widespread usage, limited safety information, and sporadic reports of hepatotoxicity, the Division of the National Toxicology Program (DNTP) initially evaluated BC extract ...
Stephanie L. Smith‐Roe, Stavros Garantziotis, Rebecca L. Church, Jeffrey C. Bemis, Dorothea K. Torous, Kim G. Shepard, Cheryl A. Hobbs, Suramya Waidyanatha, Esra Mutlu, Keith R. Shockley, Grace E. Kissling, Sandra J. McBride, Guanhua Xie, Tim Cristy, Jessica Pierfelice, Kristine L. Witt   +15 more
wiley   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

BMC Neuroscience, 2008
Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models.
Ientile Riccardo, Parisi Giulia, Currò Monica, Condello Salvatore, Ferlazzo Nadia, Caccamo Daniela   +5 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms [PDF]

St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17, 2019
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be ...
arxiv   +1 more source

Homocysteine and familial longevity: the Leiden Longevity Study.

PLoS ONE, 2011
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease.
Carolien A Wijsman, Diana van Heemst, Maarten P Rozing, P Eline Slagboom, Marian Beekman, Anton J M de Craen, Andrea B Maier, Rudi G J Westendorp, Henk J Blom, Simon P Mooijaart   +9 more
doaj   +1 more source