Results 11 to 20 of about 115,102 (75)
The intersection of COVID-19 and autoimmunity: What is our current understanding?
Pathogens and Immunity, 2021 Viral infections have historically had a complex relationship with autoimmune diseases. For patients with preexisting autoimmune disorders, often complicated by immunosuppressive therapies, there are numerous potential effects of COVID-19, a disease of ...
Nicole Eve Winchester +2 more
doaj +1 more source
PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
Nature Communications, 2021 Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell ...
Thais G. Moreira +18 more
doaj +1 more source
Clinical and Applied Thrombosis/Hemostasis, 2022 Background Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disease; its diagnosis requires meeting both clinical and laboratory criteria.
Zhenzhen Su MM +7 more
doaj +1 more source
Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases
Frontiers in Immunology, 2021 Protein S-palmitoylation is a covalent and reversible lipid modification that specifically targets cysteine residues within many eukaryotic proteins. In mammalian cells, the ubiquitous palmitoyltransferases (PATs) and serine hydrolases, including acyl ...
Yuqi Zhang +4 more
doaj +1 more source
Co-expression network analysis reveals the pivotal role of mitochondrial dysfunction and interferon signature in juvenile dermatomyositis [PDF]
PeerJ, 2020 Background Juvenile dermatomyositis (JDM) is an immune-mediated disease characterized by chronic organ inflammation. The pathogenic mechanisms remain ill-defined.
Danli Zhong +5 more
doaj +2 more sources
Chinese Expert Consensus on Juvenile Idiopathic Arthritis-associated Uveitis (2023)
Xiehe Yixue Zazhi, 2023 Juvenile idiopathic arthritis (JIA) is a common chronic rheumatologic disease in childhood. JIA-associated uveitis (JIA-U), an important extra-articular complication of JIA, is one of the major causes of childhood disability and blindness.
The Subspecialty Group of Immunology, the Society of Pediatrics, Chinese Medical Association +2 more
doaj +1 more source
Modeling Immunity to Malaria with an Age-Structured PDE Framework [PDF]
SIAM Journal on Applied Mathematics, 2023, 83(3); 1098 - 1125, 2021 Malaria is one of the deadliest infectious diseases globally, causing hundreds of thousands of deaths each year. It disproportionately affects young children, with two-thirds of fatalities occurring in under-fives. Individuals acquire protection from disease through repeated exposure, and this immunity plays a crucial role in the dynamics of malaria ...
arxiv +1 more source
Arthritis Research & Therapy, 2020 Backgrounds Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs.
You-Jung Ha +9 more
doaj +1 more source
Acta Dermato-Venereologica, 2023 Hypopigmented mycosis fungoides is a rare form of mycosis fungoides that is characterized by achromic lesions, early onset of disease, a predilection for darker skinned populations, and a predominance of CD8+ T cells.
Zhong-Hui Hu +7 more
doaj +1 more source
SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells
Cell Reports, 2018 A balance between Th17 and regulatory T (Treg) cells is critical for immune homeostasis and tolerance. Our previous work has shown Serum- and glucocorticoid-induced kinase 1 (SGK1) is critical for the development and function of Th17 cells. Here, we show
Chuan Wu +6 more
doaj +1 more source