Microridge-like structures anchor motile cilia [PDF]
Nature Communications, 2022 Several tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease.
Takayuki Yasunaga +13 more
doaj +8 more sources
The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision [PDF]
Nature Communications, 2022 Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains
Paul W. Chrystal +29 more
doaj +10 more sources
The methylome of motile cilia. [PDF]
Mol Biol CellCilia are highly complex motile, sensory, and secretory organelles that contain perhaps 1000 or more distinct protein components, many of which are subject to various posttranslational modifications such as phosphorylation, N-terminal acetylation, and ...
King SM +3 more
europepmc +6 more sources
Assessing motile cilia coverage and beat frequency in mammalian in vitro cell culture tissues [PDF]
Royal Society Open Science, 2023 Cilia density, distribution and beating frequency are important properties of airway epithelial tissues. These parameters are critical in diagnosing primary ciliary dyskinesia and examining in vitro models, including those derived from induced ...
Ricardo Fradique +7 more
doaj +5 more sources
The regulatory roles of motile cilia in CSF circulation and hydrocephalus [PDF]
Fluids and Barriers of the CNS, 2021 Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine.
Vijay Kumar +5 more
doaj +9 more sources
Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia. [PDF]
Int J Mol Sci, 2021 Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated
Pinto AL +7 more
europepmc +7 more sources
IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. [PDF]
PLoS Genetics, 2023 Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the ...
Zeineb Bakey +25 more
doaj +4 more sources
Neuronal coordination of motile cilia in locomotion and feeding. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Efficient ciliary locomotion and transport require the coordination of motile cilia. Short-range coordination of ciliary beats can occur by biophysical mechanisms.
Marinković M, Berger J, Jékely G.
europepmc +7 more sources
Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. [PDF]
Mol Biol Cell, 2022 Hydrodynamic flow produced by multi-ciliated cells is critical for fluid circulation and cell motility. Hundreds of cilia beat with metachronal synchrony for fluid flow.
Soh AWJ +10 more
europepmc +4 more sources
Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis. [PDF]
Front Cell Dev Biol, 2022 It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 + 2 pattern) in kidney biopsies of 11 ...
Eymael J +9 more
europepmc +4 more sources